Anterior Chamber Depth With Peripapillary Nerve Fiber Layer Thickness Pak Armed Forces Med J 2018; 68 (2): 250-53 250 CORRELATION OF ANTERIOR CHAMBER DEPTH WITH PERIPAPILLARY NERVE FIBER LAYER THICKNESS Bilal Hassan, Haroon Javaid, Muhammad Saim Khan, Shafaq Rabbani, Muhammad Asad Farooq, Asim Mehboob Combined Military Hospital Peshawar Pakistan ABSTRACT Objective: To determine correlation of anterior chamber depth with peripapillary nerve fiber layer thickness. Study Design: Descriptive cross sectional study. Place and Duration of study: Armed Forces Institute of Ophthalmology Rawalpindi, from Apr 2016 to Oct 2016. Patients and Methods: Anterior chamber depth and peripapillary nerve fiber layer thickness was measured in 200 eyes of 110 patients, between 10-40 years of age. Anterior chamber depth was measured in mm, by taking average of 3 readings, measured by optical biometry (IOL Master, Carl Zeiss Meditec, Dublin whereas average peripapillary retinal nerve fibre layer pRNFL thickness was obtained by taking average of 12 segments RNFL thickness measurement, calculated by Spectral domain optical coherence tomography (SD OCT) (3D OCT-1000 Markll, Topcon Co, Tokyo, Japan) after dilating pupils with one drop of 1% Tropicamide, instilled three times, 10 minutes apart. Three readings were taken for each eye. The mean of the three readings was used for the analysis. Pearson correlation (+1/-1) was calculated between anterior chamber depth, peripapillary nerve fiber layer thickness and age. Results: Two hundred eyes of 110 patients were included in the study. Both eyes were considered in 90% of the patient, however only Right eye was considered in 6.3% of the patients while left eye in 3.7% of the patients. Mean age of the patients was 26.58 ± 8.88 years. Mean visual acuity of patients measured by log MAR was 0.52 ± 0.12. Mean Anterior chamber depth (ACD) of patients was 3.41 ± 0.35 while mean RNFL appeared to be 103.26 ± 8.89 um. Conclusion: It was concluded that anterior chamber depth was neither related significantly with peripapillary nerve fiber layer nor with age. Keywords: Anterior chamber depth, Glaucoma, Peripapillary nerve fiber layer thickness. INTRODUCTION Anterior chamber (AC) is the aqueous humor filled cavity bounded anteriorly by the corneal endothelium and posteriorly by the plane of iris. The normal anterior chamber depth (ACD) is 2.5 mm to 3.5 mm, and is a key determinant of angle of the AC, formed between peripheral corneal endothelium and plane of the iris 1 . Measurement of ACD is of particular value in categorization of glaucoma into open angle and closed angle glaucoma. Variations in ACD has been associated with variety of glaucoma sub- types 2 . ACD assessment is helpful in evaluating angle closure, patency of peripheral iridotomies, suitability of AC implants, diagnosis of secondary glaucomas such as pigmentary, pseudoexfoliation and neovascular glaucoma 3,4 . ACD is found to vary in individuals depending upon refractive status, age, axial length, race 5 . ACD is assessed clinically by different methods which include Smith method and Van Herrick method 6 . More sophisticated instruments to measure ACD include Ultrasound biomicro- scopy, scheimpflug imaging and optical biometry 7 . Thickness of peripapillary retinal nerve fibre layer (pRNFL) has been recently considered as having pivotal importance in diagnosis of glaucoma. Since both ACD and pRNFL are dependent on axial length of eye, it may be possible that a correlation between these two ocular parameters may exist 8 . Very few studies This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Correspondence: Dr Bilal Hassan, Department of Ophthalmology, Combined Military Hospital Peshawar Pakistan Email: doctorbilalhassan@gmail.com Received: 12 Dec 2017; Revised received: 09 Mar 2018; accepted: 15 Mar 2018 Original Article Open Access