Mathematical Population Studies, 18:122–149, 2011
Copyright © Taylor & Francis Group, LLC
ISSN: 0889-8480 print/1547-724X online
DOI: 10.1080/08898480.2011.564566
Modelling Mutation to a Cytotoxic T-lymphocyte
HIV Vaccine
Bernhard P. Konrad
Faculty of Mathematics, Karlsruhe Institute of Technology, Germany
Naveen K. Vaidya
Theoretical Biology and Biophysics, Los Alamos National Laboratory,
New Mexico, USA
Robert J. Smith?
Department of Mathematics and Faculty of Medicine, The University
of Ottawa, Canada
Resistance to a postinfection HIV vaccine that stimulates cytotoxic T-lymphocytes
(CTLs) depends on the relationship between the vaccine strength, the fitness cost
of the mutant strain, and the rate of mutant escape. If the vaccine is strong
enough, both strains of the virus should be controlled by administering the vaccine
sufficiently often. However, if escape mutation to the vaccine occurs, then either
the wild type or the mutant can outcompete the other strain. Imperfect adherence
may result in the persistence of the mutant, while fluctuations in the vaccination
time—even if no vaccines are missed—may result in the mutant outcompeting the
wild type.
Keywords: adherence; cytotoxic T-lymphocytes; escape mutation; fitness cost;
impulsive differential equations; vaccination
1. INTRODUCTION
Virus-specific cytotoxic T-lymphocytes (CTLs) control HIV-1 repli-
cation in humans and SIV replication in rhesus monkeys, thereby
delaying the onset of disease and progression to AIDS (Klein et al.,
1998; Jin et al., 1999; Schmitz et al., 1999; Amara et al., 2002; Barouch
et al., 2003). Controls against SIV during trials of vaccines that
elicit CTL responses (Barouch et al., 2000; Amara et al., 2001, 2002)
Address correspondence to Robert J. Smith?, Department of Mathematics and
Faculty of Medicine, The University of Ottawa, 585 King Edward Ave, Ottawa K1N 6N5,
Canada. E-mail: rsmith43@uottawa.ca
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