Chemistry and Materials Research www.iiste.org ISSN 2224- 3224 (Print) ISSN 2225- 0956 (Online) Vol 1, No.2, 2011 1 Synthesis, Characterization, Antimicrobial Studies of Certain Triazole Containing S-Triazine Derived Compound Dr.Kokila N. Sarmah*, Talha V.Patel. *Selection Grade Lecturer, Department of chemistry, Shree Jayendrapuri Arts & Science College, Bharuch-392002. Research Student under the guidance of Dr. Kokila N. Sarmah. Worked at Shree Jayendrapuri Arts & Science College, Bharuch. Gujarat, India-392002. talha.patel9@gmail.com Abstract Some new substituted 1,3,5 triazine with 1,2,4 triazole and substituted urea/thiourea were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a microdilution procedure. Synthesized compounds 1a to 1i prove to be effective with MIC (mg ml -1 ), among them 1c, 1e, 1g showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1 H-NMR and elemental analysis. Keywords :- 1,2,4 Triazole, Substituted urea/thiourea, Cyanuric chloride and Antimicrobial activity. Introduction:- s-Triazine derivatives represent an important class of compounds due to their potential to be biologically active. They are known to be anti-protozoals [1] , anticancer agents [2] , estrogen receptor modulators [3] , antimalarials [4] , cyclin-dependent kinase modulators [5] , and antimicrobials [6] . Cyanuric chloride, an inexpensive, easily available reagent, of low toxicity and less corrosive than other similar reactants, has been widely used in organic reactions [7] . In the present research, we wish to describe a simple and efficient protocol for the rapid preparation of 1-(4-(3-(4-METHOXYPHENYL)THIOUREIDO)-6-(1H-1,2,4-TRIAZOL-1-YL)-1,3,5-TRIAZINE-2-YL)- 3-PHENYLUREA at different temperature conditions. To the best of our knowledge, there are no reports on three-component coupling of triazole, substituted urea and thiourea to produce a title compound. An important class of compounds having anticancer, antitumor, antiviral and antifungal activity consists of substituted s- triazine derivatives. These compounds have been used in the treatment of depression and hence gained considerable significance. These are valuable bases for estrogen receptor modulators [8] and also used as bridging agents to synthesize herbicides and in the production of drugs or polymers [9] . 1,3,5-Triazine derivatives [10] have displayed a broad range of biological activities including cytotoxic activities [11-13] , antiangiogenic activity by targeting either VEGF-R2 (KDR) [14] or direct modulation of Tie-2 tyrosine kinase phosphorylation [15] , antiparasitic activities [16,17] , and glucocerebrosidase inhibition with potential as chemical chaperones for Gaucher disease [18] . Cyanuric chloride derivatives have been studied for decades, especially its amino derivatives. It is generally accepted that the first chlorine of cyanuric chloride can be easily