* Corresponding Author : Geeta Chaudhary Department of Surgery College of Medicine Kufa University – IRAQ E.MAIL : deeptimandsorwale@gmail.com Copyright 2011. CurrentSciDirect Publications. IJCBMS - All rights reserved. c Antioxidative Stress Potential Of Cinnamon Zeylanicum In Type – Diabetes Mellitus a c Geeta Chaudhary , Archana Tiwari , Anoop Kumar2, Deepti MandsorwaleI, Aayush SrivastavaI , Ajai Kumar Srivastava* A R T I C L E I N F O ABSTRACT Keywords: Original article Cinnamon zeylanicum Oxidative stress Antioxidants Type–II Diabetes Mellitus. 1. Introduction There is increasing evidence that complications related to diabetes are associated with oxidative stress induced by the generation of free radicals by hyperglycemic conditions. Over the past two decades, in-vitro and in-vivo data have supported the role of cinnamon bark on glycemic control. Therefore, antioxidative stress potential of cinnamon crude bark powder preparations had been assessed. Two types of cinnamon bark powder preparations and a placebo was prepared and administered to all Type II diabetes mellitus (N=90) and normal subjects (N=90) separately and continuously for 30 days. As compared to the basal levels at 0 day of trail highly significant change had been observed in the plasma glucose, glycated hemoglobin, MDA and antioxidant defense enzyme system Catalase, GPx, GR and SOD levels with a marked and significant increase in TAP in the normal as well as in Type-II diabetic subjects. Results highly suggested a strong antioxidative stress potential of Cinnamon zeylanicum bark powder preparations. Maximum effect of the preparation boiled with tea Type –II diabetes mellitus is the most common metabolic disease worldwide, with a prevalence estimated to rise from 171 million in 2000 to 366 million in 2030 (1). The cause of diabetes mellitus is not fully understood. Recently, increasing evidence suggest that free radical formation (increased oxidative stress) is involved in the pathogenesis and the development of diabetes and in its complications (2- 4). Medicinal plants have a lot of types of antioxidants, mostly polyphenols, flavanoids which exhibits high antioxidative activity. Intake of antioxidants present in food is animportant health protecting factor. These various herbal compounds known by ancient medicine are of growing interest in the domain of prevention of the diseases. Such antioxidants are closely related with the prevention of many degenerative illnesses (5-7). A number of species and herbs have a long history of traditional use in treating elevated blood sugars levels as well as cholesterol levels (8). One such compound that has recently been the subject of intense research is cinnamon, a compound granted GRAS (generally recognized as safe) status by the United States food and drug administration. The beneficial effect of cinnamon bark on glucose control appears to be in part due to doublylinke Dpolyphenol type A compound (9). Over the past two decades, in- vitro and in-vivo data have been accumulated which support the role of cinnamon on glycemic control (10). There are established facts to show the hyperglycemia induced increased oxidative stress involving a major polyol pathway and AGEP (advanced glycation end product) formation. Therefore, the present study is an attempt to evaluate the antioxidative stresspotential role of C. zeylanicum bark powder preparation both in normal and type-II diabetic subjects. a Department of Biochemistry, GSVM, Kanpur, (UP) 208002. b Department of Medicine, RMCH, Bareilly c Department of Applied Sciences, Amity University, Delhi. Contents lists available at SciDirect Publications Current Journal homepage: www.currentscidirect.com International Journal of Current Biological and Medical Science Int J Cur Bio Med Sci. 2012; 2(2): 238-243 CurrentSciDirect Publication Copyright 2011. CurrentSciDirect Publications. IJCBMS - All rights reserved. c