Resonance Raman Spectroscopy of Xanthophylls in Pigment Mutant Thylakoid Membranes of Pea Atanaska Andreeva 1 Katerina Stoitchkova 1 Mira Busheva 2 Emilia Apostolova 2 Zsuzsanna Va ´ rkonyi 3 Gyo ¨ zo ¨ Garab 3 1 Sofia University, Faculty of Physics, Department of Condensed Matter Physics, 5, J Bourchier Blvd., 1164 Sofia, Bulgaria 2 Institute of Biophysics, Bulgarian Academy of Sciences, Acad. G. Bonchev str. bl.21, 1113 Sofia, Bulgaria 3 Institute of Plant Biology, Biological Research Center, Hungarian Academy of Sciences, Szeged, P. O.Box 521, H-6701 Hungary Received 1 September 2003; accepted 27 October 2003 Published online 7 April 2004 in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/bip.20050 Abstract: Low-temperature resonance Raman spectroscopy was used to study the changes in the molecular structure and configuration of the major xanthophylls in thylakoid membranes isolated from mutants of pea with modified pigment content and altered structural organization of their pigment–protein complexes. The Raman spectra contained four known groups of bands, 1 4 , which could be assigned to originate mainly from the long wavelength absorbing lutein and neoxanthin upon 514.5 nm and at 488 nm excitations, respectively. The overall configuration of these bound xanthophyll molecules in the mutants appeared to be similar to the wild type, and the configuration in the wild type was almost identical with that in the isolated main chlorophyll a/b light harvesting protein complex of photosystem II (LHCII). Significant differences were found mainly in the region of 4 (around 960 cm -1 ), which suggest that the macroorganization of PS II–LHCII supercomplexes and/or of the LHCII-only domains are modified in the mutants compared to the wild type. © 2004 Wiley Periodicals, Inc. Biopolymers 74: 87–91, 2004 Keywords: resonance Raman spectroscopy; xanthophylls; thylakoid membranes; pigment mu- tants; light harvesting complex photosystem II Correspondence to: Atanaska Andreeva; e-mail: andreeva@ phys.uni-sofia.bg Biopolymers, Vol. 74, 87–91 (2004) © 2004 Wiley Periodicals, Inc. 87