Naotaka Yamamoto, Futoshi Shimizu, Mitsuo Yokokawa, Satoshi Sekiguchi, Hideo Kaburaki, Motoyoshi Kurokawa and Ryutaro Himeno Web-based Grid PSE for MD Simulations using Grid PSE Builder 16 Abstract Biogrid project is one of national R&D projects on grid in IT-Program granted by Ministry of Education, Culture, Sports, Science and Technology since 2002. In this project, we consider a grid technology as a glue or a middleware to integrate observation devices, databases and computational resources for advanced life science. We have built four typical applications in life science as exemplars on grid to show the power and effectiveness of the grid middleware, i.e. protein prediction, multi-scale bio-simulation, and database federation. In addition to the current grid middleware such as Globus, the secure Grid file system and IPv6 based grid middleware becomes a foundation of these advanced applications. From 2005, we will tightly collaborate with NAREGI project which is a national R&D grid middleware project stared in 2003 in terms of the development of simulation platform and datagrid middleware. Keyword: Grid, life scientific database federation, BioPfuga, Multi-scale simulation, OGSA I. Introduction A recent paradigm shift brought about by genome sequence analyses of many different species is about to dramatically recent paradigm shift brought about by genome sequence analyses of many different species is about to dramatically change not only biological research but also everything involved in life science. Examples of such changes are partly characterized by the terms 'tailor-made An Empirical Study of Grid Applications in Life Science - Lesson learnt from Biogrid project in Japan - Susumu Date 1 , Kazutoshi Fujikawa 2 , Hideo Matsuda 1 , Haruki Nakamura 4 and Shinji Shimojo 3 Graduate School of Information Science and Technology, Osaka University 1 1-3 Machikaneyama, Toyonaka, 560-8531, Japan Information Technology Center, Nara Institute of Science and Technology 2 8916-5 Takayama, Ikoma, Nara 630-0192, Japan Cybermedia Center, Osaka University 3 5-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan The Institute for Protein Research, Osaka University 4 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan sdate @ist.osaka-u.ac.jp, fujikawa@itc.naist.jp, matsuda@ist.osaka-u.ac.jp harukin@protein.osaka-u.ac.jp, shimojo@cmc.osaka-u.ac.jp