Membrane Protein Structure: Prediction versus Reality Arne Elofsson and Gunnar von Heijne Center for Biomembrane Research, Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, SE-106 91 Stockholm, Sweden; email: arne@bioinfo.se, gunnar@dbb.su.se Annu. Rev. Biochem. 2007. 76:125–40 First published online as a Review in Advance on January 11, 2007 The Annual Review of Biochemistry is online at biochem.annualreviews.org This article’s doi: 10.1146/annurev.biochem.76.052705.163539 Copyright c  2007 by Annual Reviews. All rights reserved 0066-4154/07/0707-0125$20.00 Key Words bioinformatics, membrane protein structure prediction, topology Abstract Since high-resolution structural data are still scarce, different kinds of theoretical structure prediction algorithms are of major impor- tance in membrane protein biochemistry. But how well do the cur- rent prediction methods perform? Which structural features can be predicted and which cannot? And what can we expect in the next few years? 125 Annu. Rev. Biochem. 2007.76:125-140. Downloaded from arjournals.annualreviews.org by Ontario Council of Universities Libraries on 08/08/08. For personal use only.