Procedia Engineering Procedia Engineering 00 (2011) 000–000 www.elsevier.com/locate/procedia An efficient cryptographic protocol based on DNA chip Mohammadreza Najaftorkaman a ,Pourya Nikfard b , Maslin Masrom c , Mohammadreza abbasy a a Advanced Informatics School (AIS), International Campus, University Technology Malaysia (UTM), Kuala Lumpur b Gorgan worker house , university of applied science and technology c Razak School of Engineering and Advanced Technology,University Technology Malaysia(UTM),Kuala Lumpur, Malaysia Abstract One of the main concerns in data communication is making secure channel to transfer sensitive information. The current algorithms have shown different constrains to meet the security requirements of transmission. Therefore, information security professionals work on novel concepts of cryptographic protocols. The main objective of this paper is to propose hybrid cryptographic protocol based on DNA technology. The most striking feature of this work is to apply DNA chip (microarray) and also DNA probes to encrypt and decrypt sensitive information. Finally, we discuss that the proposed cryptographic protocol has double-layer of security (biological and computational security). © 2011 Published by Elsevier Ltd. Selection and/or peer-review under responsibility of GCSE 2011 Keywords: Cryptographic Protocols, Hybrid cryptography, DNA cryptography, DNA Chip, DNA Probes 1. Introduction In recent years, scientists believe that binary computers (digital computers) have got so many physical constrains especially in Data storage and computations. They have concentrated on DNA computers (bimolecular computer) and Quantum computers to implement these new sciences in information security area. They claimed that with two major properties of these computers which are extraordinary information density and the vast parallelism they can make good secure system [1-2]. In fact cryptography has vital role in information security. As a result, different experts work on it to develop secure cryptography algorithms. In cryptography, there are two novel techniques, namely, quantum cryptography and DNA cryptography. Quantum cryptography was invented in 1970s and many scientists have tried to develop it due to its long use in practice [3]. Although quantum computing is newborn science and it is far from implementing accurately, its potential power is the major threat to * Corresponding author. Tel.: +60-173633923. E-mail address: rntmohammad2@live.utm.my.