JKAU: Med. Sci., Vol. 15 No. 2, pp: 27-38 (2008 A.D. / 1429 A.H.) 27 Use Pattern of Oral PDE-5 Inhibitors in Jeddah, Saudi Arabia Abdulrahman M. Alahdal, PHARM.D, BCPS, Ahmad O. Noor, PHARM.D and Alaa A. Bagalagel, PHARM.D Department of Clinical Pharmacy, Faculty of Pharmacy King Abdulaziz University, Jeddah, Saudi Arabia aalahdal@hotmail.com Abstract. This study was designed to investigate the use pattern of oral phosphodiesterase Type 5 inhibitors in Jeddah, SA. All participants (n = 500) above 18 years who sought oral phosphodiesterase type 5 inhibitors from community pharmacies were included in this study. Questionnaires were distributed to a 100 community pharmacies and a computer program was used for data analysis. Of the 500 distributed questionnaires, 337 were received (response rate 67.4%), it was found that 270 (80%) of the respondents had been taking anti-erectile dysfunction drugs without consultation with their doctors and 67 (20%) of respondents had been using their drugs after consultation. The majority of the respondents, 188 (55.7%) had been using phosphodiesterase Type 5 without any medical evidence of Erectile Dysfunction as indicated by themselves, which is statistically significant (p ≤ 0.005). It was found that 115 (34.1%) of the respondents were not aware of the side effects. The correlation between satisfaction of sexual performance before and after using is (rho. = 0.516) and is highly significant (p < 0.001). There is an obvious misuse of oral phospho- diesterase type 5 inhibitors in the Jeddah community. Keywords: Erectile dysfunction, Phosphodiesterase Type 5 inhibitors, Misuse, Abuse, Community pharmacy. Introduction The prescription of drugs is one of the most important factors in the rising costs of health services in both developed and developing Correspondence & reprint request to: Dr. Abdulrahman M. Alahdal P.O. Box 80260, Jeddah 21589, Saudi Arabia Accepted for publication: 27 April 2008. Received: 26 January 2008.