Hindawi Publishing Corporation International Journal of Vascular Medicine Volume 2013, Article ID 548764, 7 pages http://dx.doi.org/10.1155/2013/548764 Clinical Study Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles Andrew W. Gardner, 1,2,3 Petar Alaupovic, 4 Donald E. Parker, 5 Polly S. Montgomery, 1 Omar L. Esponda, 6 and Ana I. Casanegra 6 1 Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK 73117, USA 2 Veterans Afairs Medical Center, Oklahoma City, OK 73104, USA 3 University of Oklahoma Health Sciences Center, O’Donoghue Research Building, 1122 NE 13th Street, Suite 1200, Oklahoma City, OK 73117, USA 4 Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA 5 Department of Biostatistics and Epidemiology, OUHSC, Oklahoma City, OK 73117, USA 6 Cardiovascular Section, Department of Medicine, OUHSC, Oklahoma City, OK 73117, USA Correspondence should be addressed to Andrew W. Gardner; andrew-gardner@ouhsc.edu Received 23 June 2013; Accepted 12 August 2013 Academic Editor: Mark Morasch Copyright © 2013 Andrew W. Gardner et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modiiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein proiles in 29 subjects with peripheral artery disease (PAD) and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein proiles of subjects with PAD either treated ( = 17) or untreated ( = 12) with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C ( < 0.05) and lower values of Lp-A-I:A-II ( < 0.05) than controls. he PAD group taking statins had lower age-adjusted values for apoB ( < 0.05), Lp-A-II:B:C:D:E ( < 0.05), Lp-B:E + Lp-B:C:E ( < 0.05), Lp-B:C ( < 0.05), and Lp-A-I ( < 0.05) than the untreated PAD group. Subjects with PAD have impaired apolipoprotein proiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk proile, particularly noted in multiple apolipoprotein subparticles. he eicacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle proile than in the more traditional lipid proile of subjects with PAD and claudication. his trial is registered with ClinicalTrials.gov NCT00618670. 1. Introduction Peripheral artery disease (PAD) is a highly prevalent medical condition, [1] and it is associated with high prevalence of co- existing vascular diseases in the coronary, cerebral, and renal arteries [2, 3]. Consequently, PAD is a deadly [4, 5] and costly disease [6]. Many patients with PAD are physically limited by ambulatory leg pain [7, 8], resulting in baseline ambulatory and physical dysfunction [9, 10], low physical activity [11, 12], and poor health-related quality of life [13]. Although PAD is considered by many to be a benign disease, as 70 to 80% of patients have stable claudication that does not progress to worsening claudication or critical limb ischemia [2], PAD patients have increased rates of functional decline and mobility loss compared to those without PAD [14], leading to higher rates of hospitalization and loss of independence [15]. We have previously found that cardiovascular risk fac- tors, such as dyslipidemia, are associated with impaired ambulation and vascular function in subjects with PAD and claudication [16, 17]. Dyslipidemia is typically evident by an elevation in low-density lipoprotein cholesterol (LDL-C). Recently, the multinational INTERHEART study showed