Haque et al., IJPSR, 2013; Vol. 4(7): 2821-2826. E-ISSN: 0975-8232; P-ISSN: 2320-5148 International Journal of Pharmaceutical Sciences and Research 2821 IJPSR (2013), Vol. 4, Issue 7 (Research Article) Received on 02 February, 2013; received in revised form, 20 June, 2013; accepted, 29 June, 2013 EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY POTENTIAL OF “AMLAPITTANTAK RAS”, AN ANTIULCERANT AYURVEDIC MEDICINE Mahamudul Haque* 1, Shamema Nasrin 1 , Firoz Ahasan 1 , Nazmul Hasan Mahmud 2 and Farhana Akter 2 Pharmacy Discipline, Khulna University 1 , Khulna-9208, Bangladesh Department of Pharmacy, University of Asia Pacific 2 , Dhaka-1209, Bangladesh ABSTRACT: This study is an effort to assess Analgesic and anti- inflammatory property of widely used Ayurvedic preparation Amlapittantak Ras. In current study, the effects of APR were evaluated through validated animal models of pain including Hot plate, acetic acid- induced writhing, formalin-induced paw licking and Xylene induced ear edema test. In hot plate method, APR treated mice at doses 200 and 400mg/Kg causes a significant (p<0.001) inhibition of writhing responses. When compared to the control it was shown percent inhibition of 57.9% and 61.7% at 4 th hour with a dose dependent manner. In Writhing test the result was significant (P<0.1 and P<0.001) with writhing inhibition 36% and 61.33% at doses 200 and 400 mg/kg respectively. In paw licking test the APR was highly significant analgesic effect (p=0.00195**) but the anti- inflammation result was not statistically significant. At dose 100mg/kg, APR treated male mice exerted a decrease in inflammation in the xylene induced ear edema test when compared to the corresponding control group, which was not statistically significant. From this result it can be concluded that though conventionally APR is indicated for hyperacidity non ulcer dyspepsia it may be the choice of drug for the treatment of Analgesia. INTRODUCTION: Ayurvedic medicine -- also known as Ayurveda -- is one of the world's oldest holistic (whole-body) healing systems. It has a long tradition behind it, having originated in India perhaps as much as 3,000 years ago. In the U.S., Ayurveda is considered a form of complementary and alternative medicine (CAM). Ayurvedic medicine is an example of a well-organized system of traditional health care, both preventive and curative, that is widely practiced in parts of Asia especially in Bangladesh, Myanmar, China, Sri Lanka and Pakistan. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.4(7).2821-26 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(7).2821-26 Today it remains a favored form of health care in large parts of the Eastern world, where a large percentage of the population uses this system exclusively or combined with modern medicine. Amlapittantak Ras is an Ayurvedic preparation which is included (page 175) in the Bangladesh National Formulary of Ayurvedic Medicine 1992 (Approved by the Government of Bangladesh vide Ministry of Health and Family Welfare Memo No. Health-1/Unani-2/89/ (Part-1) 116 dated 3-6-1991). Bangladesh National Formulary of Ayurvedic Medicine is compiled by the National Unani and Ayurvedic Formulary Committee and published by the Bangladesh Board of Unani and Ayurvedic Systems of Medicine, 38, Bangabandhu Avenue, Dhaka-1000 under the authority vested in the Board vide section 13(j) of the Bangladesh Unani and Ayurvedic practitioners Ordinance, 1983 in collaboration with the World Health Organization. Keywords: Amlapittantak Ras, Analgesic effect, Hot plate Method, Acetic acid-induced writhing Correspondence to Author: Mahamudul Haque Pharmacy Discipline, Khulna University, Khulna-9208. Bangladesh E-mail: mahamud_05@yahoo.com