Citation: Ihedioha JI and Idika IK (2007) Blood biochemical abnormalities associated with sub- chronic contamination of drinking water with low sub-lethal concentrations of inorganic fertilizers. Proceedings of the 44 th Annual Congress of the Nigerian Veterinary Medical Association, 44: 202 – 209. Blood biochemical abnormalities associated with sub-chronic contamination of drinking water with low sub-lethal concentrations of inorganic fertilizer. J. I. Ihedioha and I. K. Idika Department of Veterinary Pathology and Microbiology, University of Nigeria, Nsukka, P. O. Box 3236 Nsukka 410001, Enugu State, NIGERIA. E-mail of corresponding author: jiiferh@yahoo.com Abstract This study investigated the effects of sub-chronic contamination of drinking water with low sub-lethal concentrations of inorganic fertilizer on some clinically significant blood biochemical indices of liver and kidney function. 50 male albino rats of 10 – 11 weeks of age were used for the study. They were divided into five groups (groups A – E) of 10 rats each and given drinking water experimentally contaminated with NPK:15-15-15 fertilizer at the level of 2%, 1%, 0.5%, 0.1% and 0% (uncontaminated control) w/v respectively for a period of 14 weeks. Relevant clinical biochemical tests of liver and renal function were carried out following standard procedures. Results showed that group A rats (2% fertilizer contamination) had a significantly lower (p<0.05) serum alanine amino transferase (ALT), aspartate amino transferase (AST) and fasting plasma glucose level (FPGL), and a