Publication Ref No.: IJPRD/2011/PUB/ARTI/VOV-3/ISSUE-1/MARCH/023 ISSN 0974 – 9446          www.ijprd.com 231 FORMULATION AND EVALUATION OF SOLID DISPERSIONS OF GLIPIZIDE FOR DISSOLUTION RATE ENHANCEMENT M.R.Shivalingam* 1 , T.Jyothibasu 2 , Y.V.Kishore Reddy 1 , AppaRao. B 1 , V.Tejaswi 1 , D.Nagaanusha 1 1 Department of Pharmaceutics, Victoria College of Pharmacy,Guntur, AndhraPradesh, India 2 A.S.N College of Pharmacy,Tenali, AndhraPradesh, India Email:shiva24carat@gmail.com ABSTRACT Glipizide is a class-II antidiabetic drug which is purely insoluble in water. Since only dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is ultimately desired. Solubility of the poorly soluble drug is enhanced by formulating solid dispersion using solvent evaporation method. Drug and carrier in different ratios like 1: 1, 1: 2, 1: 3 by keeping drug weight constant was considered for formulating solid dispersions. Then prepared solid dispersions were evaluated for their routine tests like Phase solubility, Invitro dissolutoion study and the results were observed and tabulated. FT-IR study was also done for drug, polymers and formulated solid dispersion having(1: 3) ratios of drug:carrier by KBr pellet method. From the study it was concluded that 1: 3 ratio of drug:carrier shows better phase solubility and invitro dissolution rate. Also it was confirmed from the FTIR Spectra that no extra peaks were observed indictes no interaction between drug and polymers in the formulated solid dispersions. Key Words: Poor solubility, Solid dispersion, Solvent evaporation method, Increased dissolution rate. INTRODUCTION More than 90% of the drugs arrowed since 1995 have poor solubility, poor permeability and more than 40% of new chemical entities have little or no water solubility. Absorption of drug into the systemic blood circulation by dermal, pulmonal, nasal, sublingual, or gastro-intestinal administration always involves transport of separate (dissolved) drug molecules through an absorbing membrane. Solubility place a great M.R.Shivalingam