INTERNATIONAL JOURNAL OF MEDICAL AND APPLIED SCIENCES ISSN:2320‐3137 101 www.earthjournals.org Volume 2 Issue 4 2013 Research Article COMPARISON OF ORAL AND IV CLONIDINE FOR ATTENUATION OF HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND INTUBATION GAUTAM A 1 , RAI S 2 * 1. Assistant Professor , Department of Anaesthesiology, Gajra Raja Medical College and Hospital, Gwalior, M.P , India 2. Assistant Professor, Department of Physiology, Index Medical college and Research center, Indore , M.P , India ABSTRACT Clonidine has anti-hypertensive properties and augments the effect of anaesthesia. The objective of this study was to evaluate the attenuation ofhemodynamic responses to oral clonidine and IV clonidine to laryngoscopy and tracheal intubation. The study was carried out on 60 adult patients of either sex, in the age group 18-65 years. All the patients were belonging to ASA grade I and II. Patients were divided into 2 groups of 30 patients each. Depending upon the drugs employed patients were randomly allotted to either group. Group I (n=30): received oral clonidine 3µg/kg 90 minutes before induction. Group II (n=30): received IV clonidine 3µg/kg before induction. To study the effect of clonidine on cardiovascular changes during laryngoscopy and intubation pulse rate, systolic blood pressure and diastolic blood pressure were recorded before induction of anesthesia, before laryngoscopy, just after intubation, 1 mins after intubation and 5 mins after intubation. This denotes that clonidine had depressant action of sympathetic outflow via α2 receptors and prevent rise in arterial pressure and pulse rate. IV clonidine is rapidly acting, safe and significantly better in terms of maintaining stable hemodynamic responses as evidenced by lesser rises in pulse rate, Systolic and diastolic blood pressure than oral clonidine in the doses taken for the study. iv clonodine provided an acceptable level of sedation in comparison of oral clonidine. Keywords : clonidine, intubation, laryngoscopy INTRODUCTION: Endotacheal intubation demanded greater skill from the anesthesiologist and required deeper planes of anaesthesia for successful intubation. Cardiovascular complication arising during laryngoscopy and transient disturbances in cardiac action caused by reflex excitation of vagus nerves or sympathetic system during laryngoscopy and intubation. The haemodynamic response to laryngoscopy and tracheal intubation namely hypertension, arrythmias and tachycardia, are of considerable importance to anesthesiologist. Clonidine is an alpha-2 adrenergic agonist, initially introduced as centrally acting antihypertensive agent has been shown to reduce sympathetic out flow in response to stress.It increases cardiac baroreceptor reflex sensitivity to increase in systolic blood pressure and thus stabilizes blood pressure.The present study was performed to compare the effect of oral