American Journal of Phytomedicine and Clinical Therapeutics www.ajpct.org Original Article Evaluation of In-vitro Antioxidant Potential of Whole Plant of Various Extracts of Trianthema decandra . Natarajan suresh 1 , Shubhranshu shekhar 1 , J.Amutha Iswarya Devi 2 , D. Satheesh Kumar 3 and A. Kottai Muthu* 2 1 Sree Balaji Medical College and Hospital, Chrompet, Chennai. 2 Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, India. 3 Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, Tirupati-517 102. ABSTRACT The present investigation was to examine the in-vitro antioxidant potential of various extracts of whole plant of Trianthema decandra by different in-vitro methods. The antioxidant activity was determined by DPPH activity, superoxide radical scavenging and iron chelating activity. An IC 50 value was found that methanolic extract of Trianthema decandra is more effective in free radical scavenging activity than that of other two extracts. So, the in-vitro studies clearly showed that the methanolic extract of Trianthema decandra has a significant antioxidant activity. These in-vitro assays indicate that this plant extracts is a better source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses. Keywords: In-vitro antioxidant, DPPH activity, Superoxide radical activity, Iron chelating activity. INTRODUCTION Oxygen-derived free radicals such as super oxide anion and hydroxyl radical are cytotoxic and promote tissue injuries. Antioxidants act as a major defense against radical-mediated toxicity by protecting against the damages caused by free radicals 1 . The cellular antioxidant status determines the susceptibility to oxidative damage and is usually altered in response to oxidative stress 2 . Antioxidants may be defined as radical scavengers which protect the human body against free radicals that may cause pathological conditions such as ischemia, anemia, asthma, arthritis, inflammation, neurodegenertion, Parkinson's diseases, mongolism, ageing process and perhaps dementias. Flavonoids and flavones are widely distributed secondary metabolites with antioxidant and antiradical properties 3 . Trianthema decandra (Aizoaceae) is a prostrate, glabrous, succulent, annual herb found almost throughout India. It is Address for Correspondence Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, India. Tel. +91-9443171712 E-mail: arthik03@yahoo.com