American Journal of Phytomedicine and Clinical Therapeutics www.ajpct.org Original Article An Overview of Immunology - Systemic Review P. Parveen 1 , P.Usha 1 , Ch.Sowjanya 1 , S.V.R.L.Sravika 1 , Bhavana Ragala 1 , and M. Gayatri Ramya 2* 1 Hindu College of Pharmacy Amaravathi Road, Guntur-522002 India. 2 Acharya Nagarjuna University, University college of Pharmaceutical Sciences, Nagarjuna Nagar, Guntur-522510 India. ABSTRACT Immunology is one of the most rapidly developing areas of medical biotechnology research and has great promises with regard to the prevention and treatment of a wide range of disorders such as the inflammatory diseases. In addition, infectious diseases are now primarily considered immunological disorders, while neoplastic diseases and organ transplantation and several autoimmune diseases are involved in an immunosuppressive state. Immunomodulators are natural or synthetic substances that help regulate or normalize the immune system. Immunomodulators correct immune systems that are out of balance. The benefits of immunomodulators stem from their ability to stimulate natural and adaptive defense mechanisms.A number of disorders such as immunodeficiency state, autoimmune disease, cancer and viral infection can be treated with immunostimulants drugs. The immune system is a part of body to detect the pathogen by using a specific receptor to produce immediately response by the activation of immune components cells, cytokines, chemokines and also release of inflammatory mediator. They modulate and potentiate the immune system. Keywords: Immunomodulators, Immunosuppressive, Immunology. INTRODUCTION The immune system is designed to protect the host from invading pathogens and to eliminate disease. The primary object in the past has been to suppress immune system to permit allotransplantation. Activation of immune system by “non-self” antigen (alloantigen) or “self” antigen (auto antigen) is generally believed to require processing of the antigen by the phagocytic cells such as macrophages, monocytes, or related cells. There are two types of immune response are occurs in the human body: I) Innate immune response II) Adaptive immune response a. Humoral immunity b. Cellular immunity Address for Correspondence Acharya Nagarjuna University, University College of Pharmaceutical Sciences, Nagarjuna Nagar, Gunt ur-522510 India. E-mail: rajuph111 @gmail.com