RAF CONTROL OF MITOCHONDRIAL ROS AND CALCIUM Survival signaling by C-RAF: mitochondrial ROS and Ca 2+ are critical targets Andrey V. Kuznetsov 1,3 , Julija Smigelskaite 1,3 , Christine Doblander 1 , Manickam Janakiraman 1,4 , Martin Hermann 2 , Martin Wurm 2 , Stefan Scheidl 1 , Robert Sucher 1 , Andrea Deutschmann 2 and Jakob Troppmair* 1 1 Daniel Swarovski Research Laboratory; 2 KMT Laboratory, Department of General- and Transplant Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria Running Title: RAF CONTORL OF MITOCHONDRIAL ROS AND Ca 2+ *Corresponding author: Jakob Troppmair, Daniel Swarovski-Research Laboratory, Department of General- and Transplant Surgery, Innsbruck Medical University (IMU), Innrain 66, 6020 Innsbruck, Austria, Tel: +43 512 504 24624; Fax: +43 512 504 24625; E-Mail: jakob.troppmair@i-med.ac.at 3 These authors contributed equally to this work 4 Current address: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. Key words: apoptosis; RAF; ROS; Ca 2+ ; mitochondria ACCEPTED Copyright © 2008, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. Mol. Cell. Biol. doi:10.1128/MCB.00683-07 MCB Accepts, published online ahead of print on 22 January 2008