Journal of Computer Applications (JCA) ISSN: 0974-1925, Volume VI, Issue 2, 2013 28 Abstract - The visualization of datasets with two or more dimensions is a vital role in a medical image analysis and research. It normally based on the orientation, region or progression (time) of structures in clinical and non clinical datasets. The actual quantification of the data is typically required to evaluate regions-of-interest (ROIs) or volumes-of-interest (VOIs). It may be either one slice or multiple slices throughout the dataset. The look up table (LUT) in an image datasets is used to highlight structures of interest, control the magnification level and adjust the transfer function. This paper focuses the image datasets of brain and explains the functional brain metabolism of a healthy and Alzheimer’s disease in terms of clinical variables. Index Terms – Nuclear image, ROI, VOI, LUT, functional metabolism, Alzheimer’s Disease. I. INTRODUCTION Image datasets analysis and quantification is a challenging task for medical image research. Medical images are derived from various modalities, such as microscopy, microarray data, X-ray, CT, MRI, fMRI, and PET. To analyze an image dataset, researchers may use several factors such as personal preference, data requirements, software limitations, and precedent. The datasets must be able to read and write in industry formats such as DICOM, TIFF, Analyze and RAW. The physician must understand the structures of an image datasets for subsequent treatment of patients. The attributes for quantification such as volume and various tissue types are used to study the diagnosis, monitor and treat various disorders. Medical image segmentation is used to identify anatomic structures of images as members of a general group. Many segmentation methods are subjectively changed due to user interaction. Manual VOI adjustments of the boundary are basically operator dependant. Statistical calculations on masked and contoured VOIs are improved reproducibility [1]. The image datasets have to be processed by a sequence of transformation steps. Each image has to be rotated and translated such that they all fit into the same frame. The resultant portions are saved to an ASCII text file. I. PET SCAN IMAGE A Positron Emission Tomography (PET) is also known as PET imaging or a PET scan, is a type of nuclear medicine imaging. This scan image detects chemical and physiological changes related to functional metabolism. Meena A, Research Scholar, Dept of CSE, Sathyabama University, Chennai, Tamilnadu. (E-mail: kabimeena2@hotmail.com) Dr. Raja K, Dean (Academics), Alpha College of Engineering, Chennai, Tamilnadu. (E-mail: raja_koth@yahoo.co.in) It can be used to monitor human body substances such as glucose, ammonia, water, oxygen and blood flow during activation of specific areas. It uses a radioactive substance (tracer) to look for disease in the body [2]. The presence of disease measures the unusual occurrence of the substances. Cancerous tissue contains more level of glucose normally known as a type of sugar than normal body tissue [3]. It will show up as a bright area on the PET scan image. This scan images are more sensitive than other image techniques such CT and MRI [4]. II. ALZHEIMER’S DISEASE Alzheimer’s Disease (AD) is a condition where the brain slowly goes down, as well as a serious loss of thinking ability in a person and cognitive impairment. PET scan image is mainly used for the Alzheimer’s neurological disorder treatment and other kind of dementia. In 2006, there were 26.6million sufferers worldwide. Alzheimer's is predicted to affect 1 in 85 people globally by 2050[10]. Every five years after the age of 65, the risk of acquiring the disease approximately doubles, increasing from 3 to as much as 69 per thousand person years. Normally women are having a higher risk of developing AD [9]. Brain imaging using PET can validate Alzheimer’s will typically show a reduction in glucose use in the cerebral cortex. The brain outermost layer is more responsible for many complex brain functions including memory, verbal and consciousness. The below figure shows the healthy human brain functional metabolism and patient with Alzheimer’s disease using PET scan [13]. Figure1. Healthy human brain functional metabolism A Study on Functional Brain Metabolism using PET Scan Image Datasets – An Analysis A.Meena a, *, Dr. K.Raja b,1