www.iajpr.com Page9213 Indo American Journal of Pharmaceutical Research, 2013 ISSN NO: 2231-6876 Journal home page: http://www.iajpr.com/index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH Antihepatotoxic Potential of Cucumis sativus and Pogostemon patchouli against Carbon tetrachloride induced Hepatotoxicity S. R. Dhande*, P. P. Dongare, P. R. Shah, Dr Y. M. Joshi, V.J. Kadam Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, sector-8, C.B.D. Belapur, Navi Mumbai-400614, India. Corresponding author Ms Swati Dhande Assistant Professor of Department of Pharmacology, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C.B.D. Belapur, Navi Mumbai-400614, India dswatir@gmail.com Copy right © 2013 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 09/11/2013 Available online 30/11/2013 Keywords Carbon tetrachloride, Cucumis sativus, Hepatotoxicity, Pogostemon patchouli, Silymarin. Cucumis sativus (Cucumber), a very commonly used plant in India and Pogostemon patchouli (Patchouli), a herb from traditional Chinese medicine have been screened earlier for antioxidant activity which is considered to be basic action required for an organ protective action. The present study was aimed to evaluate hepatoprotective potential of Cucumis sativus and Pogostemon patchouli against carbon tetrachloride (CCl 4 ) induced hepatotoxicity in rats. A single i.p injection of 1ml of CCl 4 /kg body weight in olive oil (1:1) induced liver marker enzymes such as alkaline phosphatase (ALP), serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), bilirubin (TBIL) and distorted the hepatic tissue architecture along with increased levels of lipid peroxides (LPO) and reduction of total protein (TPROT), catalase (CAT) and reduced glutathione (GSH) in liver tissue. Treatment groups receiving higher doses of both plant extracts significantly (p<0.01) restored the levels of all biochemical parameters and antioxidant system of the body towards standard control. Extent of lipid peroxidation was also found to be less (p<0.05), restoring the structural integrity of hepatocytes as compared to disease group. Silymarin was used as standard drug. Result interpretation supported hepatoprotective role biochemically and histologically. Thus above plants can be further studied for isolation of responsible active components, deducing possible way of mechanism of action of these plants in liver protection. Please cite this article in press as S. R. Dhande et al. Antihepatotoxic Potential of Cucumis sativus and Pogostemon patchouli against Carbon tetrachloride induced Hepatotoxicity. Indo American Journal Of Pharm Research.2013:3(11).