Research Article Sourabh Tiwari, IJPRBS, 2012 Ava CYTOTOXICITY EFFECT CHEMOTHERAPEUTIC DR *SOURABH TIWARI 1, 2 , RAV 1. Department of Resear 2. Department of Biotec 3. Department of Biotec Accepted Date: 13/09/2012 Publish Date: 27/10/2012 Keywords Solid lipid Nanoparticle 5-Fluorouracil Ca-Leucovorin Irinotecan Corresponding Author Ms. Sourabh Tiwari Department of Research, Bhopal Memorial Hospital & Research centre, Bhopal India. 2; Volume 1(5): 250-260 ailable Online At www.ijprbs.com T OF NANO-ENGINEERED CARRIERS EN RUG ON HUMAN COLORECTAL ADENO LINE VI UPADHYAYA 2 , RUCHI SHROTI 3 , SHARAD TR rch, Bhopal Memorial Hospital & Research c chnology, Govt. P.G. College, Pipariya, India. chnology, Govt. P.G. College, Hoshangabad, Abstract Intense research has led to a m understanding of cancer at the gene cellular levels providing a possibility increasing antitumor efficiency of dr systemic side effects. Nanoparticles an delivery is a far more effective antit conventional chemotherapy, which is typ toxicity of drugs to normal tissues, shor in plasma, limited aqueous solubility, restricting therapeutic efficacy. The u chemotherapy is hampered due to obs specificity, side effects, drug resistance chemotherapeutic compounds. These partially overcome by encapsulating t Nanoparticles (SLN). Measures of anti-ca of the nano-engineered formulations we cultured carcinoma cells. Evaluation potential by Annexin-V-FITC/PI apoptosi h treatment with SLN and native drugs d differences, establishing better potenti engineered drugs. ISSN: 2277-8713 IJPRBS NCAPSULATING OCARCINOMA CELL RIVEDI UPADHYAYA 3 centre, Bhopal India. . India. more comprehensive etic, molecular and y for methods of rugs while reducing nd their use in drug tumor method than pically limited by the rt circulation half-life and non-selectivity use of conventional stacles such as poor and poor stability of obstacles may be them as Solid lipid arcinogenic potential ere investigated using of anti-carcinogenic is assay following 48 delineated significant ial efficacy of nano-