www.iajpr.com Page1513 Indo American Journal of Pharmaceutical Research, 2013 ISSN NO: 2231-6876 Journal home page: http://www.iajpr.com/index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH SYNTHESIS, CHARACTERIZATION AND IN-VITRO ANTIMICROBIAL STUDY OF SERIES OF 1-((SUBSTITUTED ARYL/ALKYL)SULFONYL)-4-TOSYLPIPERAZINES Mohan N R 1 , Sreenivasa S 1* , Manoj Kumar K E 1 , Anitha H C 1 , Madhu Chakrapani Rao T 2 , Thippeswamy B S 3 , Vijay K Gowda 4 1 Department of Studies and Research in Chemistry, Tumkur University, Tumkur - 572 103, Karnataka, INDIA 2 Tadimety Aromatics Pvt. Ltd, Hirehalli Industrial Area, Tumkur - 572 168, Karnataka, INDIA 3 Department of Pharmacology, Sree Siddaganga College of Pharmacy, Tumkur - 572 102, Karnataka, INDIA 4 Department of Studies and Research in Environmental Science, Tumkur University, Tumkur-572 103, Karnataka, INDIA Corresponding author Dr. Swamy Sreenivasa Associate Professor and Chairman Department of Studies and Research in Chemistry Tumkur University, Tumkur -572103 Karnataka (state), INDIA drsreenivasa@yahoo.co.in drsreenivasa@tumkuruniversity.in Copy right © 2013 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 14/11/2013 Available online 30/12/2013 Keywords Bis-sulfonylpiperazine , Trifluroacetic acid, Antimicrobial. A new series of bis-sulfonyl piperazines were taken up for synthesis by inserting two sulfonyl groups at 1 st and 4 th position of piperazine in search of potent antimicrobial agents. An imperative intermediate 1-tosylpiperazine was accomplished through deprotection of di-tert- butyl dicarbonate group from 4-tosylpiperazine-1-carboxylate by using trifluroacetic acid. Further 1-tosylpiperazine upon electrophilic substitution reaction using appropriate substituted sulfonyl chlorides gave 1-((substituted aryl/alkyl)sulfonyl)-4-tosylpiperazines 8a-k as targeted series of bis-sulfonyl piperazines. The design, synthesis, FT-IR, 1 H NMR, 13 C NMR, LC-MS spectral characterizations, elemental analysis and their in-vitro antimicrobial potency is discussed in this communication. Compounds 8f, 8j and 8k are proved to be potent antimicrobial agents. Please cite this article in press as Mohan N R et al., Synthesis, characterization and in-vitro antimicrobial study of series of 1- ((substituted aryl/alkyl)sulfonyl)-4-tosylpiperazines. Indo American Journal Of Pharm Research. 2013:3(12).