Didwagh and Piste, IJPSR, 2013; Vol. 4(6): 2045-2061. ISSN: 0975-8232 International Journal of Pharmaceutical Sciences and Research 2045 IJPSR (2013), Vol. 4, Issue 6 (Review Article) Received on 05 January, 2013; received in revised form, 09 March, 2013; accepted, 29 May, 2013 GREEN SYNTHESIS OF THIAZINE AND OXAZINE DERIVATIVES - A SHORT REVIEW Sayaji S. Didwagh and Pravina B. Piste* P.G. Department of Chemistry, Yashavantrao Chavan Institute of Science, Satara-415 001, Maharashtra, India ABSTRACT: A survey of green synthesis of thiazines and oxazines revealed the moiety have attracted a great deal of interest of medicinal chemist, biochemist, pharmacologist and rendered as a lead molecule for designing potential bioactive agents. This review accompanying supplementary green synthetic information & its references would extend great deal of help to researchers in determining the best and most productive, economical, suggestive and clinically important compound of thiazine and oxazine derivatives which will be expected to show potent pharmacological activities. This has led to the discovery of a wide variety of compounds that are of high interest from the point of view antimicrobial, antimycobacterial, antidiabetic and antidepressant effects among others. INTRODUCTION: Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. The large numbers of biologically active molecules that contain heterocyclic rings has play important roles in the drug discovery process and exhibit various biological activities. A literature survey identified several thiazine and oxazine derivatives in the development phase as potential new drugs. The versatility of the thiazine and oxazine skeleton, in addition to its relative chemical simplicity and accessibility, makes these chemicals amongst the most promising sources of bioactive compounds. The aim of this review is generalization of the data published up to 2012 on the synthesis of Thiazines and Oxazines derivatives. QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.4(6).2045-61 Article can be accessed online on: www.ijpsr.com The present survey has clearly demonstrated that thiazine and oxazine may be successfully used to synthesize a wide variety of heterocycles of academic and pharmaceutical interest. Moreover, in general, the desired compounds may be obtained in a single step with high yield. This has been noticed so far, that the modifications on thiazine and oxazine moiety displayed valuable biological activities and these modifications can be utilized to develop potentially active agents in future. Thus, the quest to explore many more modifications on thiazine and oxazine moiety needs to be continued. So we have decided to review briefly on novel green synthetic methodologies of Thiazine and Oxazine Derivatives. MATERIALS AND METHODS: We have collected data up to 2012 on synthesis of thiazine and oxazine derivatives especially by using International Journals Such as Int. J. of Pharmaceutical Sciences, Tetrahedron Letters, Organic Communication, Journal of Catalysis, Monatsh Chem., J. Med. Chem., J. Iran Chem., Org, Lett., Int. J. Res. Pharm.Sci., Bio.Org. Med. Chem., Bull. Org. Medicinal Chemistry, Bull Korean Chem. Soc. etc. Keywords: Thiazine, Oxazine, Green synthesis, Biological activities Correspondence to Author: Dr. Mrs. Pravina B. Piste Associate Professor in Chemistry, P.G. Department of Chemistry, Y.C. Institute of Science, Satara, Dist: Satara-415001, Maharashtra, India E-mail: ppiste321@gmail.com