IJPSS Volume 4, Issue 2 ISSN: 2249-5894 ___________________________________________________________ A Monthly Double-Blind Peer Reviewed Refereed Open Access International e-Journal - Included in the International Serial Directories Indexed & Listed at: Ulrich's Periodicals Directory ©, U.S.A., Open J-Gage, India as well as in Cabell’s Directories of Publishing Opportunities, U.S.A. International Journal of Physical and Social Sciences http://www.ijmra.us 1 February 2014 COMPARATIVE ASSESSMENT OF ANTIBACTERIAL ACTIVITIES OF ASCLEPIAS SYRIACA (MILK WEED) LEAF EXTRACT AND ANTIBIOTIC DRUGS ON METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS, STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS FAECIUM Rufai K Olufemi * Solesi A Obafemi* Adegbite A Ayoade ** Adebanjo A Adedapo* ABSTRACT This study was carried out to comparatively assess the antibacterial activities of the leaves extract of Asclepias syriaca (Milk weed) with antibiotics commonly used in the study area (gentamycin, tetracycline and ampiclox) on Methicillin Resistant Staphylococcus aureus, Staphylococcus aureus and Stretococcus faecium. The study employed standard procedures to prepare the extract of the Asclepias syriaca, and then at the five concentration levels of 1mg/ml, 5mg/ml, 25mg/ml, 50mg/ml and 100mg/ml, the growth and inhibitions of Methicillin Resistant Staphylococcus aureus (MRSA), Staphylococcus aureus and Stretococcus faecium were examined. The results showed that the three bacteria species were found resistant to the antibacterial properties of the plant and no inhibition occurs at 1mg/ml but only at 25mg/ml for MRSA and inhibition occurs at 5mg/ml for both Staphylococcus aureus and Stretococcus faecium. The results further showed that the zones of inhibition increases as the concentration increases given different zones of inhibition ranging from 8.6mm – 15mm at MIC level and * Department of Pharmaceutical Techniques, Ogun State College of Health Technology, Ilese-Ijebu, P.M.B. 2081 Ijebu-Ode-Nigeria ** Department of Water Resources Management and Sanitation, Ogun State College of Health Technology, Ilese-Ijebu, P.M.B. 2081 Ijebu-Ode-Nigeria