____________________________________________________________________________________________ *Corresponding author: E-mail: ysaif@med.bsu.edu.eg; Ophthalmology Research: An International Journal 2(4): 212-218, 2014, Article no. OR.2014.005 SCIENCEDOMAIN international www.sciencedomain.org Combined Trabeculectomy with Beta Irradiation with and without Intravitreal Bevacizumab for Neovascular Glaucoma Sawsan Abdel Sabour 1 , Mohamed Yasser S. Saif 2* , Ahmed Tamer S. Saif 3 and Passant S. Saif 4 1 Department of Ophthalmology, Azhar University, Egypt. 2 Department of Ophthalmology, Beni Suef University, Egypt. 3 Department of Ophthalmology, Fayoum University, Egypt. 4 Department of Ophthalmology, Misr University for Science and Technology, Egypt. Authors’ contributions All authors manage and examine the cases, follow up the cases, share in writing and editing, of the manuscript. Received 11 th December 2013 Accepted 13 th March 2014 Published 12 th April 2014 ABSTRACT Purpose: To evaluate the efficacy and safety of intravitreal bevacizumab (IVB) and adjunctive Strontium-90 (Sr 90 ) beta radiotherapy with trabeculectomy in the management of neovascular glaucoma (NVG). Methods: Thirty seven eyes with NVG were randomly selected and divided into two groups according to the treatment given Group 1: Trabeculectomy with Beta-irradiation (n=18 eyes). Group 2: Preoperative (IVB) followed after two weeks by trabeculectomy and Beta- irradiation (n=19 eyes). Intraocular pressure (IOP), and regression of rubiosis iridis (NVI) are the used outcome measures. Results: By 6 months postoperatively, the mean IOP levels decreased from 38.6mmHg pre-operatively to 11.3mmHg on the first postoperative week and 16.2 at the end of follow up for all cases. No significant difference between both groups as regard of success, while group 2 (IVB) showed more regression of NVI and less incidence of complications. Conclusion: Preoperative IVB combined with filtration surgery and adjuvant Strontium-90 (Sr 90 ) beta radiotherapy is a safe and effective method of controlling intraocular pressure in NVG. Original Article Research