32 International Journal of Scientific Study | January 2014 | Vol 1 | Issue 4 32 International Journal of Scientific Study | January 2014 | Vol 1 | Issue 4 Hospital Based Study of Dengue Hemorrhagic Fever in Western Uttar Pradesh Region V K Singh 1 , J M Haria 2 , S K Jain 3 1 Associate Professor, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, 2 Associate Professor, Department of Medicine, Teerthanker Mahaveer Medical College & Research Centre, Moradabad, 3 Professor Anatomy, Department of Anatomy, Teerthanker Mahaveer Medical College & Research Centre, Moradabad Corresponding Author: Dr. S K Jain, Professor Anatomy, Dept of Anatomy, TMMC&RC, Moradabad E-mail: drskjain2005@rediffmail.com According to (Bharaj et al, 2008) 3 four serotypes of the virus are circulating in India. In 1996 another major widespread epidemic of dengue hemorrhagic fever (DHF) occurred involving areas around Delhi and Lucknow. 4,5 After there has been resurgence of the infection in north Indian plains including Uttar Pradesh. DHF occurs throughout the year with a peak during monsoon and post-monsoon season due to high vector density. Major outbreaks have occurred in north India. 6 In the last 50 years, incidence has increased 30-fold with increasing geographic expansion to new countries beyond national borders. 7 The objective of present retrospective study was to determine the number of DHF cases admitted to the INTRODUCTION Dengue is the most rapidly spreading mosquito-borne viral disease in the world. Dengue fever (DF) and Dengue hemorrhagic fever (DHF) is endemic Western Pacific region. DHF is defined as an acute febrile illness with hemorrhagic, a platelet count <100,000/mm 3 and objective evidence of plasma leakage due to increased vascular permeability, shown by either a fluctuation in hematocrit ≥ 20% during the course of illness and recovery or clinical signs of plasma leakage, such as ascites, pleural effusion, or hypoproteinemia. 1 (WHO, 1997). The first virologically confirmed epidemic in India occurred at Kolkata and in the eastern coast of India in 1963-1964. 2 Original Article Abstract Background: Dengue hemorrhagic fever is Arbo virus mediated outbreak, hitting different geographic areas with typical and atypical manifestations. Dengue hemorrhagic fever emerged as major health problem in India. Here in this study we have tried to find out the trend of DHF in western Uttar Pradesh region. Material & Methods: In this study we retrospectively studied the case files of 196 patients who were admitted as the case of Dengue/ Dengue haemorrhagic fever, but we included only those cases in this study, which fulfilled the World Health Organization case definitions for DHF. Blood samples from suspected cases were collected and tested for Dengue by ELISA. Results: Among all cases fever was present in all the cases and other noticeable symptoms were, headache, Rash, Pleural effusion, Bleeding, Neurological deficits & Ascites. Various biochemical parameters showed different values. Conclusions: We concluded our study with the fact that while keeping in mind the common symptoms of DHF, we should keep an eye on atypical symptoms and manifestations also, so that no case should go unnoticed and proper treatment modality should be applied on the patients. Keywords: ELISA, WHO, Dengue Virus Infection, Fever