M9:00519-MCP_revised IDENTIFICATION OF A HORMONE-REGULATED DYNAMIC NUCLEAR ACTIN NETWORK ASSOCIATED WITH ESTROGEN RECEPTOR ALPHA IN HUMAN BREAST CANCER CELL NUCLEI* Concetta Ambrosino 1,2 , Roberta Tarallo 1 , Angela Bamundo 1 , Danila Cuomo 1 , Gianluigi Franci 1 , Giovanni Nassa 1 , Ornella Paris 1,3 , Maria Ravo 1 , Alfonso Giovane 4 , Nicola Zambrano 5 , Tatiana Lepikhova 6 , Olli A. Jänne 6 , Marc Baumann 7 , Tuula A. Nyman 8 , Luigi Cicatiello 1,3 , and Alessandro Weisz 1,3,9 1 Department of General Pathology, Second University of Naples, Napoli, Italy; 2 Department of Biological and Environmental Sciences, University of Sannio, Benevento, Italy; 3 AIRC Naples Oncogenomics Center, Napoli, Italy; 4 Department of Biochemistry and Biophysics ‘F. Cedrangolo’, Second University of Naples, Napoli, Italy; 5 CEINGE Biotecnologie Avanzate and Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Napoli, Italy; 6 Institute of Biomedicine (Physiology) and 7 Protein Chemistry Unit, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; 8 Protein Chemistry Research Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland; 9 Molecular Medicine Laboratory, Faculty of Medicine and Surgery, University of Salerno, Baronissi, Italy. Running title: Nuclear ERα-β-actin network in breast cancer cells Corresponding author: Alessandro Weisz Dipartimento di Patologia generale Seconda Università degli Studi di Napoli vico L. De Crecchio, 7 80138 Napoli (Italy) Tel./Fax (39+) 081 441655 alessandro.weisz@unina2.it