CHEMICAL CONSTITUENTS OF Cinnamomum trichophyllum D. L. Espineli, 1 E. M. G. Agoo, 2 C.-C. Shen, 3 and C. Y. Ragasa 1, * 1) Chemistry Department and Center for Natural Sciences and Ecological Research, De La Salle University, 2401 Taft Avenue, 1004, Manila, Philippines, fax: (+0632) 536 02 30, e-mail: consolacion.ragasa@dlsu.edu.ph ; 2) Biology Department and Center for Natural Sciences and Ecological Research, De La Salle University, Manila, Philippines; 3) National Research Institute of Chinese Medicine, 155-1, Li-Nong St., Sec. 2, 112, Taipei, Taiwan. Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2014, pp. 336–337. Original article submitted October 15, 2012. Chemistry of Natural Compounds, 50(2):389-290, May 2014 Cinnamomum trichophyllum Quis. & Merr. (Lauraceae) grows in mid-elevation mountains in the Philippines and Indonesia [1]. To date, there are no reported chemical studies and biological activities of C. trichophyllum. There are 21 species of Cinnamomum found in the Philippines, of which 16 are known to be endemic. This study was conducted as part of our research on the chemical constituents of Cinnamomum species found in the Philippines. We report herein the isolation and identification of the chemical constituents of the dichloromethane extracts of the bark and leaves of C. trichophyllum from Jamildan, Capiz, Philippines. The leaves of C. trichophyllum yielded eugenol (1) [2], β-sitosterol (2) [3], and polyprenol (3) [4], while the bark afforded trilinolein (4) [5] and a mixture of β–sitosterol (2) and stigmasterol (5) [3]. To the best of our knowledge, this is the first report on the isolation of these compounds from C. trichophyllum. Eugenol (1) is a constituent common to five Philippine Cinnamomum species, namely, C. cebuense [6], C. iners [7], C. utile [8], C. trichophyllum, and C. rupestre [9]. It was reported to be cytotoxic against HL-60 leukemia cells [10], human osteoblastic cell line U2OS [11], human HFF fibroblasts, and human HepG2 hepatoma cells [12]. It also possesses significant antioxidant, anti-inflammatory, analgesic, local anesthetic, and cardiovascular activities [13]. β-Sitosterol (2) is a constituent of five Philippine Cinnamomum species, namely, C. iners [7], C. utile [8], C. trichophyllum, C. rupestre, and C. nanophyllum [9]. It inhibited the proliferation and induced apoptosis in human solid tumors such as colon and breast cancers [18]. Polyprenols (3) are constituents found in five Philippine Cinnamomum species, namely, C. cebuense [6], C. griffithii [14], C. utile [8], C. trichophyllum, and C. rupestre [9]. They exhibited hepatoprotective effects [15], significant triglyceride and cholesterol lowering effects [16], and chemotherapeutic properties on human breast cancer cells [17].