Research Article Explore the Antimicrobial Potential from Organic Solvents extract of Brown Seaweed ( Sargassum longifolium) alleviating to pharmaceuticals M. MALINI 1 , M. PONNANIKAJAMIDEEN 1 , C. MALARKODI 1 , S. RAJESHKUMAR 2∗ 1 EnvironmentalNanotechnology Division,Sri Paramakalyani Centre for Environmental Sciences,ManonmaniamSundaranar University, Alwarkurichi – 627412, Tamil Nadu, India. 2 Department of Biochemistry,, AdhiParasakthi College of Arts and Sciences, Kalavai - 632506, Tamil Nadu, India. ABSTRACT Marine macro algae Sargassum’s are commonly referred to as brown seaweeds. Commercially and continuously the pharmaceuticals industries are rapidly growing because always demand for new drug discovery is encouraged. Since brown seaweeds have ample source of bioactive compounds of primary or secondary metabolites. These potential bioactive compounds interest to improve the pharmaceuticals industry. This present study was investigated to explore the antibacterial and antifungal activity of the organic solvents extracts of the brown seaweed Sargassum. Phytochemical analysis of Brown seaweeds of Sargassum longifolium with six different organic solvents was analysed. The solvents like Dimethyl Sulfoxide, Benzene, Acetic acid, hexane, Di Ethyl ether and Chloroform has the extraction of phytochemical constituents. Among the six solvents Dimethyl Sulfoxide extract showed maximum number of phytochemical constituents and antibacterial and antifungal activity when compared to other five solvent extracts. The responsible functional groups in the solvent extract were identified by FTIR. These results statements be a necessary (or) recommended that the species of brown seaweeds (Sargassum longifolium) having a potential capacity as a source of antimicrobial compounds, which makes them interesting for screening for natural and highly bioactive secondary metabolites products it may leads to development of new pharmaceutical agents. Key words: Sargassum longifolium, Brown seaweed, Phytochemicals, Antimicrobial Assay, FTIR. ∗ Address for correspondence Dr. S. Rajeshkumar, Assistant Professor, Department of Biochemistry, AdhiParasakthi College of Arts and Sciences, Kalavai - 632506, Tamil Nadu, India. E.mail: j3ssrajesh@gmail.com, srajeshkumar@sify.com, Phone: +91-9629739263, Received: 30/12/2013, Revised: 18/01/2014, Accepted: 28/01/2014 INTRODUCTION Algae‘s are very large and important aquatic diverse groups found in marine and fresh water [1]. Algae are divided into three classes, chlorophyceae (green algae), phaeophyceae (brown algae) and Rhodophyceae [2] (red algae). Land plants resources have most exhausted to produce traditional and modern medicines. However, the biological and chemical diversity of marine source initiate a new type of agents against many diseases [3, 4]. Marine algae’s are a rich source of biologically active metabolites [5, 6]. Many marine algae highly produced secondary (or) primary metabolites may be these poten- tial bioactive compounds are used in many pharmaceu- tical industry [7]. Now a day’s many unique chemical compounds of marine origin have various biological activities. Some of them screened and under investiga- tion and others are being used to develop new pharma- ceutical agents. In marine macro algae‘s are concern because it have wide range of biological activities such as antioxidant [8], antifungal [9], anticancer [10], antivi- ral [11] and antimicrobial activities [12]. The numerous reports macro algae chemical compounds used phar- maceutical‘s in broad range because they produce bio- active substances and chemically active metabolites, in their surroundings as an aid to product themselves against other settling organisms like bacteria and fungi [13]. Seaweeds are primitive non-flowering plants without true root leaves and stem and commercially essential 28 | International Journal of Pharmaceutical Research | January-March 2014 | Volume 6 | Issue 1