©2014, Copyright by the Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Go to iovs.org to access the version of record. For permission to reproduce any abstract, contact the ARVO Ofice at pubs@arvo.org. ARVO 2014 Annual Meeting Abstracts 127 Spatial and temporal vision Sunday, May 04, 2014 1:30 PM–3:15 PM Exhibit/Poster Hall SA Poster Session Program #/Board # Range: 758–790/D0001–D0033 Organizing Section: Visual Psychophysics / Physiological Optics Program Number: 758 Poster Board Number: D0001 Presentation Time: 1:30 PM–3:15 PM Contrast Sensitivity in Patients with Cataract: Comparing Pelli- Robson with SPARCS Testing Methods Victor Cvintal, Radha Delvadia, Yi Sun, Ellif Erdem, Camila Zangalli, Lan Lu, Sheryl S. Wizov, Jesse Richman, Eric Spaeth, George L. Spaeth. Wills Eye Hospital, Philadephia, PA. Purpose: The ability to discern contrast is an important aspect of vision. Cataracts affect this ability. Presently, a frequently used method to determine contrast sensitivity (CS) is the Pelli-Robson Chart (P-R), which evaluates central CS based on the ability to read Sloan Letters, organized into triplets of decreasing contrast. The Spaeth/Richman Contrast Sensitivity (SPARCS) test uses alternate black and white square wave bars, which test CS centrally and also in four peripheral quadrants. The purpose of the present study is to compare the results of determining CS using PR and SPARCS in healthy controls and in those with cataract. Methods: Patients with cataract and age-matched normal controls were prospectively evaluated using PR and SPARCS, version H2/ H3. Testing was performed in each eye separately in a standardized testing environment. SPARCS contrast scores were determined for central, right upper (RUQ), right lower (RLQ), left upper (LUQ) and left lower quadrants (LLQ). PR and SPARCS scores for each area of vision in cataract patients were compared with age-matched controls. Results: Forty-three eyes from 23 patients and 119 eyes from 61 controls were analyzed. The mean scores for SPARCS in the center quadrant were 13.4 and 14.44 in the cataract and control groups, respectively (p<0.001). PR mean scores were 1.32 and 1.45 in the cataract and control groups, respectively (p<0.001). Intraclass correlation coeficients for patients with cataract were 0.76 for PR and 0.61 for SPARCS. There was excellent agreement between the ability of PR and SPARCS to detect the effect of cataract on central CS. Conclusions: This study illustrates the signiicant inluence of cataract on CS, both centrally and peripherally. SPARCS offers the advantage of determining contrast peripherally as well as centrally. SPARCS is a user-friendly, highly speciic and sensitive method of determining CS, without inluence of effects of visual acuity or literacy. Commercial Relationships: Victor Cvintal, None; Radha Delvadia, None; Yi Sun, None; Ellif Erdem, None; Camila Zangalli, None; Lan Lu, None; Sheryl S. Wizov, None; Jesse Richman, Patent # 8.042,946 (P); Eric Spaeth, Patent # 8.042,946 (P); George L. Spaeth, Alcon Laboratories (F), Alcon Laboratories (R), Allergan, Inc. (F), Allergan, Inc. (R), Merk U.S. Human Health (F), Merk U.S. Human Health (R), Merk U.S. Human Health (R), Patent # 8.042,946 (P), Pizer Ophthalmics (F) Support: Pizer Inc. (Grant) Clinical Trial: NCT01300949 Program Number: 759 Poster Board Number: D0002 Presentation Time: 1:30 PM–3:15 PM Spatial Contrast Sensitivity is Associated with Human Responsivity to Pain Michele E. Mercer 1 , Geoff L. Smith 1 , Paul A. Sheppard 1 , Jessica R. Butler 1 , Nicole R. Pelley 1 , Russell J. Adams 1, 2 . 1 Psychology, Memorial University, St John’s, NF, Canada; 2 Pediatrics, Memorial University, St John’s, NF, Canada. Purpose: Last year (ARVO, 2013) we reported a surprising relationship between two seemingly independent sensory modalities, namely human vision and pain. Speciically, adults’ ability to tolerate heat and pressure pain was negatively correlated with performance on tests of spatial contrast sensitivity (CS). However, this effect was found in a very small sample of adults who were tested repeatedly in order to reduce intra-subject variability. To better evaluate the robustness of this effect, and to explore the possible neural mechanisms that may underlie sensory interactions, we evaluated the relationship between pain and both spatial and temporal vision within a much larger group of young adults. Methods: Three measures of spatial contrast sensitivity (FACT, Vector Vision, Rabin) and both temporal photopic and mesopic licker fusion thresholds were assessed binocularly in 105 healthy young adults (M = 23 y; 62 females, 43 males). Within the same session, adults’ threshold and tolerance to both contact heat (arm) and pressure pain (pinky inger) was also assessed. Results: Analyses revealed strong correlations between all measures of spatial CS and heat pain tolerance (all r > - 0.65), although results for pressure pain were more modest. More speciically, those who showed lower tolerance for heat pain (i.e., were more sensitive to pain) also showed higher levels of spatial contrast sensitivity. Conversely, temporal measures of critical licker fusion thresholds appeared uncorrelated with pain threshold or tolerance. Conclusions: These results provide further evidence that human adults show a relationship between heat pain sensitivity and spatial vision, but not between pain and the present measures of temporal vision. Given that dopamine is heavily involved in both the processing of pain as well as spatial information in the visual cortex, this raises the interesting possibility that the observed co-variation in sensitivity may be explained by dopaminergic involvement. Commercial Relationships: Michele E. Mercer, None; Geoff L. Smith, None; Paul A. Sheppard, None; Jessica R. Butler, None; Nicole R. Pelley, None; Russell J. Adams, None Support: NSERC (Canada), Janeway Hospital Research Foundation Program Number: 760 Poster Board Number: D0003 Presentation Time: 1:30 PM–3:15 PM Photopic and scotopic spatio-temporal contrast sensitivity function in adult zebraish Nadine Hollbach 1, 2 , Christoph Tappeiner 2 , Anna Jazwinska 3 , Volker Enzmann 2 , Markus Tschopp 1, 2 . 1 Ophthalmology, University Hospital of Basel, Basel, Switzerland; 2 Ophthalmology, University Hospitalcof Bern, Inselspital, Bern, Switzerland; 3 Biology, University of Fribourg, Fribourg, Switzerland. Purpose: The aim of the study was to investigate the spatio-temporal contrast sensitivity functions (CSFs) of adult zebraish (Danio rerio) under photopic and scotopic conditions by assessing the optokinetic relex. To date, in zebraish, CSFs were only measured cursory at photopic light levels. Detailed CSFs help to better understand the visual system of zebraish, e.g. whether it is tuned to spatial frequency, speed or temporal frequency. Furthermore, CSFs allow the identiication of ideal test conditions for visual functions. Methods: Contrast sensitivity threshold was measured using a modiied commercially available optomotor device (OptoMotry,