Case Report Giant Endometrial Polyp in a Postmenopausal Woman without Hormone/Drug Use and Vaginal Bleeding Betül Ünal, 1 Selen DoLan, 2 Fatma Feyda Karaveli, 1 Tayup FimGek, 2 Gülgün ErdoLan, 1 and IGJl Candaner 1 1 Department of Pathology, School of Medicine, Akdeniz University, 07070 Antalya, Turkey 2 Department of Obstetrics and Gynecology, School of Medicine, Akdeniz University, 07070 Antalya, Turkey Correspondence should be addressed to Bet¨ ul ¨ Unal; betulunalmd@gmail.com Received 6 May 2014; Accepted 13 June 2014; Published 29 June 2014 Academic Editor: Giampiero Capobianco Copyright © 2014 Bet¨ ul ¨ Unal et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. he objective of this study is to determine and discuss the causes of a giant endometrial polyp in a postmenopausal woman without hormone/drug use and to submit interesting clinical presentation. Here we report a seventy-year-old female patient who was admitted to our hospital with lower back pain. here were no other complaints from her. Physical examination was normal. For further examination, computed tomography was performed and a heterogeneous mass, with a diameter of 10 × 9 centimeters, was detected in the uterine cavity. Hysterectomy because of suspected endometrial cancer was performed. Histopathological examination showed us a giant endometrial polyp with edematous and focal ibrotic stroma, large thick walled blood vessels between normal sized and cystically dilated endometrial glands. To the best of our knowledge, this is the irst report of a giant endometrial polyp which is unrelated to use of drugs such as tamoxifen and raloxifene; however, based on the history of the patient it may be associated with long-term consumption of thyme, which is a kind of phytoestrogen. 1. Introduction Endometrial polyps are localized overgrowth of endometrial glands and stroma through the uterine cavity. his benign disease afects 25% of women [1]. hey protrude into the endometrial cavity and oten have secondary changes. he stroma of the polyp is composed of ibroblast-like spindle cells and large blood vessels with thick walls. he epithe- lium of the polyp may be active, pseudostratiied, or, in postmenopausal period, inactive, lat. Polyps are the com- mon causes of vaginal bleeding in perimenopausal period. However, they are associated with postmenopausal bleeding, infertility, and menorrhagia [2]. Endometrial polyps occur with increased frequency ater tamoxifen exposure. hey are characteristically multiple, large, and ibrotic. Giant endome- trial polyps associated with tamoxifen and raloxifene use were reported in previous studies [3–5]. he prevalence of malignancy with endometrial polyps is 1–3% [6]. he risk factors of malignancy within polyps are ageing, obesity, arterial hypertension, postmenopausal period, and tamoxifen [2]. In addition B. P. Lasmar and R. B. Lasmar [1] reported that endometrial polyps larger than 15mm are associated with hyperplasia and Wang et al. [7] identiied that polyps measuring more than 10 mm are associated with malignancy. Development of endometrial polyps is afected by unbal- anced estrogen therapy, estrogen-like efect, and unbal- anced estrogens and progestins. Many estrogen mimics are produced by plants (phytoestrogens (PEs)). PEs are found abundantly in foods, herbs, and spices commonly consumed by humans. It is reported that ER-binding herbal extracts are agonists, much like estradiol; however, PR-binding extracts are neutral or antagonists [8]. Here we presented a giant endometrial polyp in a post- menopausal woman without vaginal bleeding and hormone or drug use. As interesting as her clinical presentation, she had long-term consumption of thyme, which is a kind of PE. Hindawi Publishing Corporation Case Reports in Obstetrics and Gynecology Volume 2014, Article ID 518398, 4 pages http://dx.doi.org/10.1155/2014/518398