Copyright @ 200 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited. 9 ACSM POSITION STAND Appropriate Physical Activity Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults POSITION STAND ABSTRACT Overweight and obesity affects more than 66% of the adult population and is associated with a variety of chronic diseases. Weight reduction reduces health risks associated with chronic diseases and is therefore encouraged by major health agencies. Guidelines of the National Heart, Lung, and Blood Institute (NHLBI) encourage a 10% reduction in weight, although considerable literature indicates reduction in health risk with 3% to 5% reduction in weight. Physical activity (PA) is recommended as a component of weight management for prevention of weight gain, for weight loss, and for prevention of weight regain after weight loss. In 2001, the American College of Sports Medicine (ACSM) published a Position Stand that recommended a minimum of 150 minIwk j1 of moderate- intensity PA for overweight and obese adults to improve health; however, 200–300 minIwk j1 was recommended for long-term weight loss. More recent evidence has supported this recommendation and has indicated more PA may be necessary to prevent weight regain after weight loss. To this end, we have reexamined the evidence from 1999 to determine whether there is a level at which PA is effective for prevention of weight gain, for weight loss, and prevention of weight regain. Evidence supports moderate- intensity PA between 150 and 250 minIwk j1 to be effective to prevent weight gain. Moderate-intensity PA between 150 and 250 minIwk j1 will provide only modest weight loss. Greater amounts of PA (9250 minIwk j1 ) have been associated with clinically significant weight loss. Moderate- intensity PA between 150 and 250 minIwk j1 will improve weight loss in studies that use moderate diet restriction but not severe diet restriction. Cross-sectional and prospective studies indicate that after weight loss, weight maintenance is improved with PA 9250 minIwk j1 . However, no evidence from well-designed randomized controlled trials exists to judge the effectiveness of PA for prevention of weight regain after weight loss. Resistance training does not enhance weight loss but may increase fat-free mass and increase loss of fat mass and is associated with reductions in health risk. Existing evidence indicates that endurance PA or resistance training without weight loss improves health risk. There is inadequate evidence to determine whether PA prevents or attenuates detrimental changes in chronic disease risk during weight gain. This document is an update of the 2001 American College of Sports Medicine (ACSM) Position Stand titled ‘‘Appropriate Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults’’ (68). This Position Stand provided a variety of recommendations such as the identification of adults for whom weight loss is recommended, the magnitude of weight loss recommended, dietary recommendations, the use of resistance exercise, the use of pharmacological agents, behavioral strategies, and other topics. The purpose of the current update was to focus on new information that has been published after 1999, which may indicate that increased levels of physical activity (PA) may be necessary for prevention of weight gain, for weight loss, and prevention of weight regain compared to those recommended in the 2001 Position Stand. In particular, this update is in response to published informa- tion regarding the amount of PA needed for weight management found in the National Weight Control Registry (155) and by the Institute of Medicine (67). This update was undertaken for persons older than 18 yr who were enrolled in PA trials designed for prevention of weight gain (i.e., weight stability), for weight loss, or pre- vention of weight regain. Investigations that include older adults (i.e., older than 65 yr) are not abundant. Some con- cerns exist for the need for weight loss in older adults and for loss of fat-free mass and potential bone loss. This review considers the existing literature as it applies to the general population. However, it is likely that individuals vary in their response to PA for prevention of weight gain, for weight loss, and for weight maintenance. Successful results will also depend on energy intakes [Weight management. J Am Diet Assoc. 2009;109(2):330–46]. Trials with individuals with comorbid conditions that acutely affect weight and trials using pharmacotherapy were not included (i.e., acquired immunodeficiency syndrome, type 1 diabetes). Trials using SPECIAL COMMUNICATIONS 0195-9131/09/4102-0459/0 MEDICINE & SCIENCE IN SPORTS & EXERCISE Ò Copyright Ó 2009 by the American College of Sports Medicine DOI: 10.1249/MSS.0b013e3181949333 This pronouncement was written for the American College of Sports Medicine by Joseph E. Donnelly, Ed.D. (Chair); Steven N. Blair, PED; John M. Jakicic, Ph.D.; Melinda M. Manore, Ph.D., R.D.; Janet W. Rankin, Ph.D.; and Bryan K. Smith, Ph.D. 459