Implication of Oxidative Stress-Induced Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegeneration and Cancer 101 Gjumrakch Aliev, Gregory Burzynski, Ghulam Md Ashraf, Nasimudeen R. Jabir, Ramon Cacabelos, Valery V. Benberin, and Stanislaw R. Burzynski Contents Introduction .................................................................................... 2326 APP, Presenilins, and Neuronal Cell Cycle Reactivation .................................... 2328 BRCA1 as a Marker of DNA Damage and Cell Cycle Changes in AD ..................... 2329 Emerging Role of the DJ-1/PARK7 in Prevention of Neurodegeneration .................. 2330 PTEN, PINK1, and DJ-1 in Regulation of PI3K/Akt Pathway in Neuronal Oxidative Stress ................................................................................ 2332 Akt Role in Neuroprotection and in Neurodegeneration ..................................... 2333 Aberrant Nucleoporin Function: A Possible Link to Cancer and to Neurodegeneration .......................................................................... 2334 Connections Between Oxidative Imbalance and Cell Cycle Aberrations in Neurodegeneration .......................................................................... 2335 Main part of this chapter was originally published in Sieradzki et al., 2011. Published with kind permission of # Bentham Science Publishers 2011. All Rights Reserved. G. Aliev (*) GALLY International Biomedical Research Consulting LLC, San Antonio, TX, USA School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, GA, USA e-mail: aliev03@gmail.com G. Burzynski • S.R. Burzynski Burzynski Clinics and Burzynski Research Institute, Houston, TX, USA G.M. Ashraf • N.R. Jabir King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia R. Cacabelos EuroEspes Biomedical Research Center, Institute for CNS Disorders and Genomic Medicine, Camilo Jose ´ Cela University, Bergondo, La Corun ˜a, Spain V.V. Benberin Medical Center of the Administration of the President of the Republic of Kazakhstan, Astana, Kazakhstan I. Laher (ed.), Systems Biology of Free Radicals and Antioxidants, DOI 10.1007/978-3-642-30018-9 # Springer-Verlag Berlin Heidelberg 2014 2325