Clinical Materials 4 (1989) 61-76 zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQPONMLKJIHGFE Blood Plasma Proteins and Blood Cells on Polyurethane and Alkylsiloxane Plasma Treated Polyurethane Surfaces. A Dynamic Approach b Stimulus-Response Technique. Part I: Adsorption Data Mehmet Mutlu,” Meral T. Ercanb & Erhan PiSkin” o Department of Chemical Engineering, Faculty of Engineering, ’ Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, 06532 Beytepe Campus, Ankara, Turkey (Received 25 July 1988; sent for revision 22 September 1988; accepted 18 November 1988) ABSTRACT zyxwvutsrqponmlkjihgfedcbaZYXWVUTSRQ In this study, polyurethane (PU) beads were treated with hydroxy- methyldisiloxane plasma in a glow-discharge apparatus. The extent of blood plasma proteins and blood cells deposition on the surface of untreated and treated PU was investigated by a modified bead-column system using a stimulus-response technique. The studies conducted with radio-labelled blood plasma proteins and blood cells showed that plasma glow-discharge treatment can be used to modif), the surface of PU biomaterials. A stimulus-response technique can be considered as a novel approach to investigate dynamic blood-biomaterial interactions. INTRODUCTION olymeric biomaterials are widely used in a number of clinically important implants and devices, many of which are in contact with blood. For example, oxygenators, hemodialyzers, artificial heart a circulatory assist systems, tubes, catheters and cardiovascular pros eses all contain polymeric components. When any material comes into contact with blood the initial reaction is the deposition of plasma proteins on the material’s surface. It is believed that the concentratio of the .deposited proteins depend upon their concentrations an sivities in the blood, and also on the physical and chemical characteristics of the relevant surface.‘s2 61 Clinical Materials 0267-6605/89/$03.50 @I 1989 Elsevier Science Publishers Ltd, England. Printed in Northern Ireland