The energy buﬀering ability of creane appears to able to protect cells from excessive DNA damage induced by free radicals, which seem to, in part, work through ATP depleon. This appears to be more protecve of mitochondrial DNA than it is of nuclear DNA. In rats experiencing toxic levels of doxorubicin (a chemotherapeuc agent), creane supplementaon at 0.2g/kg for 30 days appeared to signiﬁcantly protect rats from death and reduced serum levels of LDH and ALT. The two enzymes were further reduced with the addion of 0.25mg/kg Vitamin C and 400IU/kg Vitamin E . In children with lymphoblastic leukemia, who are maintaining corticosteroid chemotherapy, creatine monohydrate at 0.1g/kg is able to significantly attenuate the chemotherapy-induced gain in fat mass over 16 weeks. [450] In a sample of people with colorectal cancer, to whom creatine supplementation was given for 8 weeks to assess its interactions with chemotherapy, creatine failed to benefit muscle function or quality of life. Benefit was seen in body cell mass and phase angle (indicative of cellular viability), but only in the subsample with less aggressive chemotherapy. References : Santos RV,  et al. Chronic supplementaon of creane and vitamins C and E increases survival and improves biochemical parameters aﬅer Doxorubicin treatment in rats . Clin Exp Pharmacol Physiol . (2007) Bourgeois JM,  et al. Creane monohydrate aenuates body fat accumulaon in children with acute lymphoblasc leukemia during maintenance chemotherapy . Pediatr Blood Cancer. (2008) Kim HJ,  et al. Studies on the safety of creane supplementaon . Amino Acids. (2011) *Norman K, et al. Eﬀects of creane supplementaon on nutrional status, muscle funcon and quality of life in paents with colorectal cancer--a double blind randomised controlled trial . Clin Nutr. (2006)