32 Thanda Venkataramudu. et al. / International Journal of Biopharmaceutics. 2012; 3(1): 32-39. e- ISSN 0976 - 1047 Print ISSN 2229 - 7499 International Journal of Biopharmaceutics Journal homepage: www.ijbonline.com SOLUBILITY ENHANCEMENT OF AMISULPRIDE BY COMPLEXATION TECHNIQUE AND PREPARATION OF FAST DISSOLVING TABLET (FDT) Thanda Venkataramudu *1 , R. Arun Kumar 1 , S.M. Imroz 1 , T. Murali Krishna 2 , Swamy Hanumesh 3 Dept.of Pharmaceutics, 1 Sree Vidyanikethan College of pharmacy, Tirupati, 517102, A.P, India. 2 East West College of pharmacy, Banglore, 560091, Karnataka, India. 3 Raos College of pharmacy, Nellore, 524314, A.P, India. ABSTRACT The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Amisulpride, 4-Amino-N-[[(2RS)-1-ethylpyrrolidin-2-yl]methyl]-5-(ethylsulphonyl)-2- methoxybenzamide, exhibits anti-psychotic activities by selectively binding to dopamine D(2) and D(3) receptors in the limbic system. It is used in the treatment of psychoses, paranoid, productive schizophrenias, dysthymia. However, Amisulpride(AMP) is poorly water soluble drug, so solubility is the main constraint for oral bioavailability. An attempt has been made to increase the solubility of this drug by formulating β-cyclodextrin(β-CD) as polymer and then formulating fast dissolving tablets(FDT).Tablet formulations were prepared by direct compression technique using superdisintegrants in different concentrations. Inclusion complexes were evaluated for FT-IR, DSC and developed tablet formulations were evaluated for various pharmaceutical characteristics viz. hardness, % friability, weight variations, drug content, wetting time, disintegration time and in vitro dissolution profile. Among tablet formulations, formulation CF2 gives best disintegration and dissolution profile compared with other formulations. Results showed that β -cyclodextrin is a promising polymer for enhancing the solubility of AMP. Keywords: Amisulpride; β-cyclodextrin; Dissolution enhancement techniques; Super disintegrants; Fast dissolving tablet. INTRODUCTION Fast dissolving tablets (FDTs) are solid single- unit dosage forms that are placed in mouth, allowed to disperse/dissolve in the saliva without the need of water and provides a quick onset of action. Some drugs are Corresponding Author Thanda Venkataramudu Email: tvrnaik16@gmail.com absorbed from mouth, pharynx and oesophagus as the saliva passes down into the stomach. In such cases, bioavailability of drug is significantly greater than those observed from conventional tablet dosage form. FDTs are appreciated by a significant segment of population, particularly children and elderly, which have difficulty in swallowing conventional tablets or capsules (Bradoo R et al., 2001; Dobetti L, 2001; Lorenzp- Lamosa ML et al., 1997). The fast dissolving tablets are referred by various names by researchers like quick disintegrating, orally disintegrating, rapidly dissolving, mouth dissolve tablets IJB