Toxicology Research c2tx00010e 1 In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes Malachy McCann*, André L. S. Santos, Bianca A. da Silva, Maria Teresa V. Romanos, Alexandre S. Pyrrho, Michael Devereux, Kevin Kavanagh, Iduna Fichtner and Andrew Kellett Q3 1,10-Phenanthroline, 1,10-phenanthroline-5,6-dione, [Cu ( phendione) 3 ](ClO 4 ) 2 ·4H 2 O and [Ag( phendione) 2 ]ClO 4 are highly active, in vitro, against a range of normal and cancerous mammalian cells, fungal and insect cell lines, with the metal complexes offering a clear enhancement in activity Q4 . Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached – do not change the text within the PDF file or send a revised manuscript. Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routi- nely applied to the final version. We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made. Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: toxres@rsc.org Reprints—Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints/. Costs for reprints are below: Reprint costs Cost (per 50 copies) No of pages First Each additional 2–4 £225 £125 5–8 £350 £240 9–20 £675 £550 21–40 £1250 £975 >40 £1850 £1550 Cost for including cover of journal issue: £55 per 50 copies