PROOF
Copyright © The Chemical Society of Japan
Chemistry Letters Vol.41, No.9 (2012)
1 Combined Thiourea Dioxide-Water: An
Effective Reusable Catalyst for the Synthesis
of Polyhydroquinolines via Hantzsch Multi-
component Coupling
MCR
CHO
TUD (cat)
N
H
O
O O
O
O
OR'
O O
An aqueous solution of thiourea dioxide was found to be a recyclable catalytic media for the
efficient synthesis of polyhydroguinoline derivatives via one-step coupling of three component
coupling reaction.
Neeraj Kumar, Sanny Verma, and Suman L.
Jain*
CL-120420