www.iajpr.com Page760 Indo American Journal of Pharmaceutical Research, 2015 ISSN NO: 2231-6876 ANTIEMETIC ACTIVITY OF BERGENIN FROM PELTOPHORUM ROXBURGHII L. Farhana Tasleem, Salman Ahmed * , Iqbal Azhar Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan. Corresponding author Salman Ahmed Lecturer, Deptt. of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Pakistan; salmanahmed@uok.edu.pk Copy right © 2015 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 09/02/2015 Available online 28/02/2015 Keywords Antiemetic, Bergenin, Bioactive Compound, Drug Discovery, Peltophorum Roxburghii, Natural Product. Presented study was an initial attempt to discover bergenin as an antiemetic compound isolated from Peltophorum roxburghii L., leaves. It is the extension of antiemetic activity from methanol extract of Peltophorum roxburghii L., leaves. Antiemetic activity was assessed using copper sulfate induced emesis in chick’s model. Bergenin (25 mg/kg, p.o.) exhibited significant antiemetic activity when compare with standard drug, chlorpromazine. This is the first time that, bergenin declares antiemetic activity. Bergenin has already been evaluated positively for its anti-inflammatory activity and now this paper going to report its antiemetic activity. Both the activities of same compound may be beneficial for drug designing against the disease having anti-inflammatory and antiemetic both symptoms just like migraine. The preliminary antiemetic evaluation of bergenin was conducted on single dose due to the low yield of Bergenin. However the result was significant with reference to the standard used. Further, isolation and purification of Bergenin is in process to establish a detail data on having different doses of Bergenin. Please cite this article in press as Farhana Tasleem et al. Antiemetic activity of Bergenin from Peltophorum roxburghii L. Indo American Journal of Pharm Research.2015:5(02).