International Journal of Engineering Science Invention Research & Development; Vol. I Issue VII January 2015 www.ijesird.com e-ISSN: 2349-6185 Bharat Bhushan, Alka Bali, Satish Sardana and Gulshan Bansal ijesird, Vol. I (VII) January 2015/ 235 Synthesis of 4-Alkoxy-3-Methasulfonamido Acetophenone based potential cyclooxygenase-2- Inhibitors Bharat Bhushan, 1 Alka Bali, 2 Satish Sardana, 1 Gulshan Bansal 3 1 Department of Medicinal Chemistry, Hindu College of Pharmacy, Sonepat (Haryana) 2 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 3 Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala Corresponding author: Bharat Bhushan, 1 Department of Medicinal Chemistry, Hindu College of Pharmacy, Sonepat (Haryana) Tel: +91-130-2221568 Fax: +91-130-2221568 Email: bbhushanpharma@yahoo.com Abstract The present work was designed to synthesis novel methane sulfonamido substituted alkyl aryl ethers and establishment of authenticity and purity of the prepared compounds utilizing various spectral and chromatographic techniques. Methods: The synthetic scheme followed for the preparation of the compound AB1 and AB2 followed 2-aminophenol was subjected to Friedel craft’s acylation reaction. The next step in the synthesis scheme involved generation of ether linkage at the phenolic –OH position in AB2, resulting in final compound AB3 to AB7.The alkyl bromide which was reacted with AB2 in the presence of basic solvent pyridine giving satisfactory yield of the ether product, due to insolubility of AB2 in triethylamine. Results and conclusion: IR, Mass and NMR have confirmed the synthesis of the compounds from AB1 to AB8. Purification of the compounds was done by TLC. Hence, present study exhibited that novel methane sulfonamido substituted alkyl aryl ethers may be used as synthetic compounds for anti-inflammatory activity with minimum side effects. Key words: Antinflammatory, methane sulfonamido, analgesic, Friedel craft’s I INTRODUCTION Non steroidal anti-inflammatory drugs (NSAIDs) represent a class of drugs widely used for treatment of symptoms of acute and chronic inflammatory disorders such as osteoarthritis and rheumatoid arthritis. Selective COX-2 inhibitors have the same anti-inflammatory, antipyretic, and analgesic activities as traditional NSAIDs and are safer with respect to gastrointestinal tract side effects [1]. However COX-2 also exists and has physiological functions in various normal tissues such as kidney, pancrease, brain and female genital organs. Ever since the discovery of the COX-2 isoform of cyclo- oxygenase enzyme and its implication in inflammatory conditions, studies are being extensively pursued for the development of agents with selective COX-2/COX-1 affinity. Drug development work in this area has led to the identification of two distinct chemical classes and most of the current research in the area is basically along designing of representative compounds [2]. The diaryl substituted heterocycles is extensively studied class and several heterocyclic and carboxylic variations of the central ring have been explored. The methane sulfonyl/sulphonamide substituted aryl ethers/ thioethers represents the second chemical class with highly successful example of nimesulide [3]. All the compounds currently reported in literature possess one common structural feature i.e. the presence of CH 3 SO 2 - (methylsulfonyl) or CH 3 SO 2 NH- (methanesulfonamido) moieties on the aromatic systems. Most of the SAR studies have also been carried out the modifications in rest of the molecule, while retaining this structural feature, accepting it as a prerequisite for activity. The relatively unexplored second chemical class of aryl ether can be taken as a basic for further research. The present work was designed to synthesis novel methane sulfonamido substituted alkyl aryl ethers and establishment of authenticity and purity of the prepared compounds utilising spectral and chromatographic techniques.