www.wjpr.net Vol 4, Issue 4, 2015. 204 Mohammad et al. World Journal of Pharmaceutical Research IN VITRO MEMBRANE STABILIZING ACTIVITY OF LEAF EXTRACTS OF PAEDERIA FOETIDA (L.) Mohammad Shahriar 1 *, Md. Tanveer Ahsan 2 , Sultana Mehbuba Hossain 1 , Sayeeda Fahmee Chowdhury 1 , Mohammad Mooneem Mannan 1 , Rumana Akhter 1 , Sadia Mahmud 1 , Sabbir Hasan 1 and Syeda Najah Narjish 1 1 Phytochemistry Research Laboratory, University of Asia Pacific, Dhaka, Bangladesh. 2 Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh. ABSTRACT In this present study, the leaf extracts of Paederia foetida were subjected to evaluation of the membrane stabilizing activity by using human erythrocyte and the results were compared with standard anti- inflammatory drug, acetyl salicylic acid (ASA). In vitro membrane stabilizing activity for hypotonic solution induced haemolysis, the ethanol extract inhibited 76.92% haemolysis of RBCs as compared to 85.42% produced by acetyl salicylic acid (ASA) and during heat induced condition different organic soluble materials of Paederia foetida demonstrated 76.68%, 77.19% and 74.83% inhibition of haemolysis of RBCs respectively whereas ASA inhibited 78.04%. KEYWORDS: Paederia foetida, membrane stabilizing activity, human erythrocyte, acetyl salicylic acid. INTRODUCTION Paederia foetida is an important Ayurvedic medicinal herb. Paederia is from the Greek word paederos meaning opals, for some of the species have translucent drupes. Foetida means stinking. Its Sanskrit name is Gandha Prasirini. The word meaning in sanskrit is – it spreads bad smell. It is a unique feature of this herb. Gandha means smell, prasarini means spreading. Hindi name- Gandhaprasarani or Pasaran; English name- Chinese Flower Plant, Bengali name- Gandhabhaduliya, Gandhabhadule, Gandal. It was indicated for the treatment of gout, diarrhea, piles, dysentery, calculi, stomachic, emetic, ulcers and different type of inflammations. It has also been reported for anti-nociceptive [1] antiviral, [2] anti- World Journal of Pharmaceutical Research SJIF Impact Factor 5.045 Volume 4, Issue 4, 204-209. Research Article ISSN 2277– 7105 Article Received on 19 Jan 2015, Revised on 14 Feb 2015, Accepted on 10 Mar 2015 *Correspondence for Author Mohammad Shahriar Phytochemistry Research Laboratory, University of Asia Pacific, Dhaka, Bangladesh.