International Journal of Medical Science Research and Practice UNIT OF AXIS JOURNALS International Peer Reviewed Medical Journal Committed for Excellence Print ISSN: 2349-3178 Online ISSN: 2349-3186 International Journal of Medical Science Research and Practice  Vol 2  Issue 1  2015 16 prominent ducts and breast occupied by radiological changes at least 75% family history of breast cancer. 9 However, it has been reported that HDL-C level was either elevated or depressed in women with the breast cancer. 10 The risk for breast cancer increases with a high fat diet, obesity. 3,4 Glucose intolerance is associated with insulin resistance and is produced as a result of increased insulin secretion from β cells which later on lead to β cell exhaustion and occurrence of hyperglycemia. 11 There are few studies which show increased serum glucose levels in breast cancer patients. 12-14 The aim of this study is to compare serum lipid proﬁles and serum glucose levels between breast cancer patients and control to evaluate their relationship with breast cancer. MATERIALS AND METHODS Subjects The present study was done in the department of Pathology of Chirayu Medical College and Hospital, Bhopal, India from February 2012 to March 2014. A total of 184 subjects were INTRODUCTION Globally cancer of breast is the most common malignancy among women, whereas it is the second most common cancer among Indian women. 1 A tendency of a rising trend in incidence of breast cancer has been observed in various cancer registries in India. 2 Role of lipid in the pathogenesis of coronary heart disease has been consistently found, researchers have reported association of plasma/serum lipids and lipoproteins with different cancers. 3-6 There are several reports of elevated plasma lipid level in pre and post- menopausal breast cancer patients. 7 Epidemiological studies reveal that high-density lipoprotein-cholesterol (HDL-C) and breast cancer are inﬂuenced by variables such as dietary fat intake, alcohol consumption, body weight, country of residence, pregnancy, endogenous hormones, smoking, exercise, and socioeconomic status. 8 Serum HDL-C level has been shown to be lower in the subject with extensive mammographic dysplasia, which was deﬁned as sheet-like areas of radiological density that were distinguished from the linear densities that characterize A comparative study of serum lipid proﬁle and glucose level between breast cancer patients and controls at tertiary care hospital in India Amit Kumar Haritwal, Rajesh Kumar Chourasia, Sandeep Ojha Department of Pathology, Chirayu Medical College, Bhopal, Madhya Pradesh, India Corresponding Author: Dr. Amit Kumar Haritwal, Department of Pathology, Chirayu Medical College, Bhopal, Madhya Pradesh, India. E-mail: dramitharitwal@yahoo.com © 2015 International Journal of Medical Science Research and Practice available on www.ijmsrp.com Original Research ABSTRACT Aim: The aim of this study is to compare serum lipid proﬁles: Total cholesterol, triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol, and serum glucose between breast cancer patients and control to evaluate their relationship with breast cancer. Background: There are many researches which have reported positive as well as a negative association of plasma/serum lipids and lipoproteins and serum glucose with different cancers. Increase levels of circulating lipids and serum glucose have been associated with breast cancer risk. Materials and Methods: A total of 92 consecutive cases of histologically proven carcinoma breast along with same number of age-matched, disease-free controls were selected. Serum lipid and serum glucose levels of both cases and controls were estimated. Results: The results of this study suggest that low (HDL-C) level and high (TG) levels are associated with risk of breast cancer in Indian women while serum glucose level does not show any association with breast cancer risk. Conclusion: More studies are needed in the future to explore common modiﬁable risk factors for the development of breast cancer, so that its incidence can be reduced. Keywords: Breast cancer, lipid proﬁles, serum glucose, serum lipids