____________________________________________________________________________________________ *Corresponding author: E-mail: karlr@ulrik.uio.no; Journal of Scientific Research & Reports 3(22): 2834-2847, 2014; Article no. JSRR.2014.22.002 ISSN: 2320–0227 SCIENCEDOMAIN international www.sciencedomain.org Gut Uptake, Brain and Behaviour Tveiten D. Bioeng 1 and K. L. Reichelt 1,2* 1 The Pepide Research Unit, Lab1, Oslo No-0275, Oslo, Norway. 2 Kleve 4541, Oslo University, Blindern No-0139, Oslo, Norway. Authors’ contributions This work was carried out in collaboration between all authors. Authors TDB and KLR designed the study and wrote the first draft of the manuscript. Authors KLR and TDB managed literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JSRR/2014/10162 Editor(s): (1) Francisco Torrens, Institut Universitari de Ciència Molecular, Universitat de València, Edifici d'Instituts de Paterna, València, Spain. Reviewers: (1) Maria Gazouli, Department of Basic Biomedical Science, Lab of Biology, School of Medicine, University of Athens, Greece. (2) Anonymous, Immunosciences Lab, USA. (3) Laura de Magistris, Department Magrassi, Second University of Naples, Italy. Peer review History: http://www.sciencedomain.org/review-history.php?iid=637&id=22&aid=5959 Received 17 th March 2014 Accepted 8 th July 2014 Published 6 th September 2014 ABSTRACT Aims: To document the evidence for a gut uptake to brain axis. The many hormones, many of them peptides and shared by the intestines and the brain, will not be included in this survey. Methods: Systematic looking through journal publications by means of Pub med and collected information and authors research since 1978. Results: Food-protein antibodies, food-protein derived peptides and direct physiological evidence point to considerable effect of the digestive system on behavior and mood. Removal of specific proteins from diet ameliorates the clinical condition. Conclusion: Uptake from the gut of various substances has effect on behaviour. Review Article