1 © The Author 2015. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Genomic prediction of complex human traits: relatedness, trait architecture, and predictive meta-models Athina Spiliopoulou 1,4 , Reka Nagy 1 , Mairead L. Bermingham 1 , Jennifer E. Huffman 1 , Caroline Hayward 1 , Veronique Vitart 1 , Igor Rudan 3 , Harry Campbell 3 , Alan F. Wright 1 , James F. Wilson 3 , Ricardo Pong-Wong 2 , Felix Agakov 4 , Pau Navarro 1,† , and Chris S. Haley 1,2,†,* 1 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK 2 The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Midlothian EH25 9RG, UK 3 Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK 4 Pharmatics Limited, Edinburgh EH16 4UX, UK * To whom correspondence should be addressed. Tel: +44 (0)131 332 2471, Fax: +44 (0)131 467 8456, email: Chris.Haley@igmm.ed.ac.uk † The authors wish it to be known that, in their opinion, the last two authors should be regarded as joint Last Authors. HMG Advance Access published April 26, 2015 by guest on April 30, 2015 http://hmg.oxfordjournals.org/ Downloaded from