www.wjpps.com Vol 4, Issue 05, 2015. 890 Kurnool et al. World Journal of Pharmacy and Pharmaceutical Sciences FORMULATION AND EVALUATION OF SUBLINGUAL DRUG DELIVERY SYSTEM CONTAINING ANTI-ULCERATIVE AGENT Vijaya Kumar B S 1 , Abdul Nasir Kurnool 1 ٭, Ramchandra N. Chilkawar 2 , S E Jagadeesha 3 1 Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B. G. Nagara- 571448, Karnataka, India. 2 Department of Quality Assurance, Remidex Pharma Pvt Ltd., 2 nd Stage, Peenya Industrial Area, Bengaluru-58, Karnataka, India. 3 MSN Labs Ltd, Hyderabd., India. ABSTRACT The objective of the current study was to develop and optimize a sublingual tablet of Pantoprazole sodium which is an effective drug in the treatment of peptic ulcer such as duodenal and gastric ulcer. The tablets were prepared by direct compression method using different superdisintegrating agents such as crospovidone, sodium starch glycolate, kyrone T-314. The compatibility studies of drug and excipients were performed by FTIR spectroscopy. After examining the flow properties of the powder blends, the results are found to be within prescribed limits and indicated good flowing property, it was subjected to tablet compression. The tablets were evaluated for post compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, wetting time, and in-vitro disintegration time, in vitro drug release study. An optimized tablet formulation i.e. F9 was found which provided short wetting time of 28 sec, in-vitro disintegration time of 29sec which facilitates its faster disintegration and higher the drug content of 98.99%, the best in-vitro drug release was found to be in formulation F9 i.e. 94.01% during the end of 14min. From the above results, it indicate that formulation F9 containing equal ratio of different superdisintegrating agents (1:1:1) emerged as the overall best formulation based on drug release characteristics with p H 6.8 phosphate buffer as dissolution medium. Stability studies were carried out which indicate that selected formulation (F7, F8, F9) was stable. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES SJIF Impact Factor 5.210 Volume 4, Issue 05, 890-899. Research Article ISSN 2278 – 4357 Article Received on 26 Feb 2015, Revised on 19 March 2015, Accepted on 10 April 2015 *Correspondence for Author Abdul Nasir Kurnool Department of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, B. G. Nagara-571448, Karnataka, India.