_____________________________________________________________________________________________________ *Corresponding author: E-mail: ashrafnag@mu.edu.eg, ashrafnag@yahoo.com; European Journal of Medicinal Plants 9(1): 1-11, 2015, Article no.EJMP.17093 ISSN: 2231-0894 SCIENCEDOMAIN international www.sciencedomain.org Bioactivities of Pachypodium lamerei Drake, Family Apocynaceae, Cultivated in Egypt Dina Faek El-Kashef 1 , Ashraf Nageeb El-Sayed Hamed 1* , Hany Ezzat Khalil 1 and Mohamed Salah Kamel 1 1 Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt. Authors’ contributions This work was carried out in collaboration between all authors. All authors designed the study and wrote the protocol. Author DFEK wrote the first draft of the manuscript. Authors DFEK, ANESH and HEK managed the literature searches. Author DFE managed the analyses of the study. Authors MSK, ANESH and DFEK revised the written manuscript. All authors read and approved the final manuscript. Article Information DOI: 10.9734/EJMP/2015/17093 Editor(s): (1) Marcello Iriti, Professor of Plant Biology and Pathology, Department of Agricultural and Environmental Sciences, Milan State University, Italy. Reviewers: (1) Anonymous, Universidade Federal De Uberlândia, Brazil. (2) Anonymous, Cumhuriyet University, Turkey. (3) Simon Bernard Iloki Assanga, Lab. de Investigaciones en Bioactivos y Alimentos Funcionales (LIBAF), Sonora, México. (4) Abdullahi M. Nuhu, College of Science and Technology, Kaduna Polytechnic, Kaduna, Nigeria. (5) Anonymous, National Institute of Pathology, Romania. Complete Peer review History: http://www.sciencedomain.org/review-history.php?iid=1190&id=13&aid=9452 Received 25 th February 2015 Accepted 16 th April 2015 Published 27 th May 2015 ABSTRACT Aims: The current study estimated the anti-inflammatory, anti-pyretic, gastroprotective and anti- hyperglycemic activities in various rat models of total methanol extracts (TMEs) of different plant parts; mixture of leaves & stems (MLS) and subterranean organs (SO) and different fractions of TME of MLS of Pachypodium lamerei Drake. Additionally, we evaluated the median lethal dose (LD 50 ) of TME of MLS. Place and Duration of Study: The study was carried out for nine months in 2012 in the Department of Pharmacology, Faculty of Medicine and the Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt. Methodology: The preliminary phytochemical screening of TMEs of both MLS and SO of P. lamerei was carried out to determine secondary metabolites in the extracts. The TMEs of both MLS and SO and different fractions of TME of MLS of P. lamerei were used in the current biological study. The pharmacological activities, such as anti-inflammatory, anti-pyretic, gastroprotective, anti- Original Research Article