Open Access Journal Indian Journal of Medical Research and Pharmaceutical Sciences June 2015; 2(6) ISSN: ISSN: 2349-5340 Impact Factor (PIF): 2.672 © Indian Journal of Medical Research and Pharmaceutical Sciences http://www.ijmprs.com/ [1] BIOPSYCHOSOCIAL MODEL VERSUS BIOLOGICAL MODEL IN MANAGEMENT OF CHILDHOOD NEPHROTIC SYNDROME, SINGLE CENTER EXPERIENCE, EGYPT Doaa Mohammed Youssef*, Mohamed Adel Fouda, Omnia Samir Elseifi, Noha Osman Frere Assistant professor pediatrics, 1 pediatric department, zagazig university, egypt Professor of family medicine, 2 family medicine department, zagazig university. Egypt Lecturer of public health and community medicine, 2 community medicine department, zagazig university. Egypt Family medicine resident, 2 family medicine department, zagazig university. Egypt Abstract Keywords: Nephrotic syndrome, children, Biopsychosocial, relapses. There is a shortage in the evidence of application of Biopsychosocial in nephrotic syndrome. Objectives: to design a Biopsychosocial model for steroid sensitive nephrotic syndrome (SSNS) children 2-10 years old, in Zagazig university outpatient clinic, implement this model on the intervention group and to assess the difference between the Biopsychosocial model and the biological model regarding the outcome in those children. Methods: A Randomized controlled clinical trial-single blinded study was conducted in Zagazig university pediatric nephrology outpatient clinic on 86 child (divided randomly into intervention and control groups) Primary steroid sensitive nephrotic syndrome Aged 2-10 years. Data was collected through a sheet of three parts; biological, social and psychological, the Biopsychosocial model was formulated, structured and applied on the intervention group and the biological model on the control group for 6 months where their ideas and expectations about disease, the compliance with treatment and follow up visits and frequency of relapses between the two groups were compared. Results: There was statistically significant difference between intervention and control group in the number of relapses and compliance with treatment. Regarding compliance with follow up visits, there was a highly significant difference between intervention and control group.. There was statistically significant difference after application of the Biopsychosocial model regarding patients' ideas and expectations about the disease. Conclusion: The Biopsychosocial model is significantly more effective than the biological model in the management of (SSNS) children, so we recommend all physicians to adopt this model. Introduction. Nephrotic syndrome (NS) is classically defined as massive proteinuria (>40 mg/m 2 /hr), hypoalbuminemia (<2.5 g/dL), generalized edema, and hyperlipidemia in most cases [1]. The incidence of nephrotic syndrome is estimated to be 2–7 cases per 100 000 children per year and its prevalence rate is 16 per 100 000 children below th age of 16 in Iran [2]. A significant proportion of children with nephrotic syndrome show feature of depressed, hyperactive, or aggressive behavior. Somatic complaints, social withdrawal, and poor school performance were also observed [3]. The majority (80–90%) of patients have steroid-sensitive nephrotic syndrome (SSNS), with a very high probability of final cure. However, the disease often runs a prolonged and recurring course, affecting young children during the phase in their lives when they are growing physically as well as socially and intellectually. It is recognized to cause