www.ejbps.com 607 Obeagu et al. European Journal of Biomedical and Pharmaceutical Sciences ANTI-EPILEPTIC/ANTI-CONVULSIVE EFFECT OF OCIMUM BASILICUM SMOKE IN ALBINO RABBITS Aloh,G.S. 1 , Obeagu,Emmanuel Ifeanyi 2 , Odo Christian Emeka 1 , Stella Ngozika 3 , Okpara,kingsley Ezechukwu 4 , Ugwu Getrude Uzoma 6 and Abia, Kenneth Ugochukwu 5 1 Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. 2 Diagnostic Laboratory Unit, University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. 3 Abia State University Teaching Hospital, Aba, Abia State, Nigeria. 4 Rivers State College of Health Technology, Port Harcourt. 5 Department of Biochemistry, Ebonyi State University, Abakaliki, Nigeria. 6 School of Nursing Science, ESUT Teaching Hospital, Parklane, Enugu, Nigeria. Article Received on 23/12/2014 Article Revised on 17/01/2015 Article Accepted on 11/02/2015 ABSTRACT The ethanol, chloroform and whole -leaf extracts of Ocimum basHicum were evaluated for their anti-epiletic/anti-convulsant effects on rabbits. Convulsion was induced in these animals with over -dosage of penicillin. They were exposed to the smokes of the different extracts as they were having convulsive feats. The concentrations of glucose, creatinine and calcium in their sera were measured spectrophotometrically before, during and after convulsion. The mean calculated concentrations in the control before during and after convulsion were glucose: 107.50 ± 46,70mg/dl, creatinine: 1.55 ± 2.19mg/dl, and calcium: 9.00 ± 5.66mg/dl respectively. The mean calculated concentrations in those exposed to chloroform extract smoke before, during and after convulsion were glucose: 57.90 ± 6.61mg/dl, creatinine: 3.13 ± 1.19mg/dl, and calcium: 11.70 ± 1.56mg/dl respectively. The mean calculated concentrations in those exposed to. ethanol extract smoke before, during and after convulsion were glucose: 63.67 ± 26.21 mg/dl, creatinine: 2.70 ± 0.70mg/dl and calcium: 11.67 ± 2.50mg/dl respectively. And the mean calculated concentrations in those exposed to whole -leaf extract smoke before, during and after convulsion were glucose: 84.40 Eur opEa n Jour na l of BiomEdical A ND Pha r maceut ical sciences http://www.ejbps.com ISSN 2349-8870 Volume: 2 Issue: 1 607-621 Year: 2015 R Re es se ea ar rc ch h A Ar rt t i i c cl l e e ejbps, 2015, Volume 2, Issue 1, 607-621. *Correspondence for Author Obeagu,Emmanuel Ifeanyi Diagnostic Laboratory Unit,University Health Services, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria. Phone: +2348037369912.