Int.J.Curr.Microbiol.App.Sci (2014) 3(3): 1000-1005 1000 Original Research Article Haematological parameters among sickle cell anaemia patients in steady state and haemoglobin genotype AA individuals at Michael Okpara, University of Agriculture, Umudike, Abia State, Nigeria Obeagu Emmanuel Ifeanyi 1* , Ogbuabor Bernice Nwakaego 2 , Ikechukwu Onyinyechi Angela 3 and Chude Chineze Nwakaego 3 1 Diagnostic Laboratory Unit,University Health Services Department, Michael Okpara University of Agriculture,Umudike, Abia State, Nigeria. 2 Department of Medical Laboratory Science, ESUT Teaching Hospital, Parklane, Enugu State, Nigeria. 3 Medical Laboratory Services, Federal Teaching Hospital, Abakaliki (FETHA), Ebonyi State, Nigeria. *Corresponding author ABSTRACT Introduction Sickle-cell disease (SCD), or sickle-cell anaemia (SCA), is a hereditary blood disorder, characterized by red blood cells that assume an abnormal, rigid, sickle shape. Sickling decreases the cells' flexibility and results in a risk of various complications. The sickling occurs because of a mutation in the haemoglobin gene. Individuals with one copy of the defunct gene display both normal and abnormal haemoglobin. Life expectancy is shortened. In 1994, in the US, the average life expectancy of ISSN: 2319-7706 Volume 3 Number 3 (2014) pp. 1000-1005 http://www.ijcmas.com Keywords Sickle Cell Anaemia Patients, Haemoglobin AA Genotype, Haemato- logical parameters A great percentage of sickle cell anaemic patients in this University are in steady state because of increased level of fetal haemoglobin (HbF) in most of them but very few have minimal level of HbF which easily undergo crisis.Most of the patients were detected in the course of medical examination. Because of the delicate nature of these patients, the researchers of this study saw the necessity to carry out the study. 20 confirmed sickle cell patients were used as the patients aged 4-34 year, 14 males and 6 females and 40 subjects with haemoglobin genotypes AA were used as the controls. The study showed significant increase in WBC, Neutrophil and Lymphocytes (P<0.05), significant decrease in PCV (P<0.05) and no significant change in monocyte (P>0.05) when the mean values of the SCA patients were compared relative to HbAA subjects.SCA patients should be monitored closely and prevented from triggering factors to crisis.