Anal. Bioanal. Electrochem., Vol. 7, No. 2, 2015, 175-185 Full Paper Electrochemical Studies of Dopamine Using Titanium Dioxide Nanoparticle Modified Carbon Paste Electrode Sighanamane Ranganatha Kiran Kumar, 1 Ganjeenahalli Puttagiddappa Mamatha, 1,* Handanahally Basavarajaiah Muralidhara, 2 Kumarswamy Yogesh Kumar 2 and Maralekere Krishnegowda Prashanth 3 1 Department of Pharmaceutical Chemistry, Kuvempu University, Post Graduate Centre, Kadur, Chikmagalore Dt., Karnataka, India.-577 548. 2 Centre for Emerging Technologies, Jain University, Bangalore 562112, India 3 Department of Chemistry, P.N.S. Institute of Technology, Bangalore 562 123, India * Corresponding Author, Tel.: 9448422903 E-Mail: mamatha_gp2005@rediffmail.com Received: 18 November 2015 / Received in revised form: 8 March 2015 / Accepted: 15 March 2015 / Published online: 30 April 2015 Abstract- Titanium Dioxide (TiO2) nanoparticles were synthesized by the precipitation method. The obtained products were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). As synthesized TiO2 nanoparticles were used for the modification of carbon paste electrode (MCPE). Electrochemical determination of dopamine was carried out using phosphate buffer solution at pH 7.2. MCPE exhibit excellent electrochemical sensor for dopamine having high sensitivity and reproducibility. Potentially interfering compounds did not interfere for determination of DA at a surface of propose sensor in the optimum condition. The proposed sensor was successfully applied for the determination of DA in real samples such as DA in injections. Keywords- Dopamine, Titanium dioxide nanoparticles, Modified carbon paste electrode, Cyclic voltammetry 1. INTRODUCTION There has been considerable interest in developing methods to measure secretion neurotransmitters. Electrochemical techniques have been proven to be significantly Analytical & Bioanalytical Electrochemistry 2015 by CEE www.abechem.com