1 Acid ceramidase promotes acute myeloid leukemia survival through Mcl-1 upregulation Su-Fern Tan 1 , Xin Liu 1 , Todd E. Fox 2 , Brian M. Barth 1 , Andy Awwad 1 , Alden Dewey 1 , Mithun Vinod Shah 3 , Kathleen Broeg 1 , Kenichiro Doi 1,2 , Samy Morad 4 , Dhimant Desai 2 , Shantu Amin 2 , Mark Kester 1,2, David F. Claxton 1 , Hong-Gang Wang 1,2 , Myles C. Cabot 4 , Edward H. Schuchman 5 , David J. Feith 1 , Thomas P. Loughran, Jr 1,6 . 1 Penn State Hershey Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA; 2 Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA; 3 Division of Hematology and Department of Medical Oncology, Mayo Clinic, Rochester, MN; 4 Department of Experimental Therapeutics, John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, CA; 5 Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mt. Sinai, New York; 6 University of Virginia Cancer Center, Charlottesville, VA Corresponding author: Thomas P. Loughran, Jr., MD Director, University of Virginia Cancer Center P.O. Box 800839 Charlottesville, VA 22908-0839 tploughran@virginia.edu Tel: 434-243-9926 Fax: 434-243-6086 Scientific category: Research Article